Mélanie Durand

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The mRNAs for two isotypes of alpha-tubulin, termed T alpha 1 and T26, are known to be expressed in the rat nervous system. We have compared the expression of these two alpha-tubulin mRNAs during neural development, using RNA blotting and in situ hybridization techniques with probes directed against unique sequences of each mRNA. T alpha 1 mRNA is highly(More)
BACKGROUND Increased permeability, predominantly controlled by endothelial junction stability, is an early event in the deterioration of vascular integrity in ischemic disorders. Hemorrhage, edema, and inflammation are the main features of reperfusion injuries, as observed in acute myocardial infarction (AMI). Thus, preservation of vascular integrity is(More)
Dendritic cells (DCs) represent a heterogeneous population of antigen-presenting cells that initiate and orient immune responses in secondary lymphoid organs. In mice, lymphoid organ-resident CD8(+) DCs are specialized at cross-presentation and have developed specific adaptations of their endocytic pathway (high pH, low degradation, and high export to the(More)
Proper vessel maturation, remodeling of endothelial junctions, and recruitment of perivascular cells is crucial for establishing and maintaining vessel functions. In proliferative retinopathies, hypoxia-induced angiogenesis is associated with disruption of the vascular barrier, edema, and vision loss. Therefore, identifying factors that regulate vascular(More)
BACKGROUND Macrophages, key regulators of healing/regeneration processes, strongly infiltrate ischemic tissues from patients suffering from critical limb ischemia (CLI). However pro-inflammatory markers correlate with disease progression and risk of amputation, suggesting that modulating macrophage activation state might be beneficial. We previously(More)
The expression of somatostatin (SS) was followed during the development of rat cortical neurons growing in primary cultures. The appearance of SS mRNA is delayed in cultures of cortical neurons, where it is not readily detectable prior to 5 days in culture. Between 5 and 11 days in vitro, there is a large increase in the level of SS mRNA in these cultures.(More)
We have characterized cDNA clones of mRNAs encoding two distinct isoforms of myosin regulatory light chain expressed in rat brain. One clone, isolated from a cultured astrocyte cDNA library, is derived from a 1200-base mRNA that is expressed at high levels in cultured astrocytes, and at higher levels in the embryonic brain than in the adult brain. The(More)
Dynamic control of endothelial cell junctions is essential for vascular homeostasis and angiogenesis. We recently provided genetic evidence that ANGPTL4 is a key regulator of vascular integrity both during developmental and in hypoxia-induced pathological conditions. The purpose of the present study was to decipher the molecular mechanisms through which(More)
Ariane Galaup, PhD; Elisa Gomez, PhD; Rachid Souktani, PhD; Mélanie Durand, BSc; Aurélie Cazes, MD, PhD; Catherine Monnot, PhD; Jérémie Teillon, PhD; Sébastien Le Jan, PhD; Claire Bouleti, MD; Gaëlle Briois, Bsc; Josette Philippe, BSc; Sandrine Pons, PhD; Valérie Martin, BSc; Rana Assaly, PhD; Philippe Bonnin, MD, PhD; Philippe Ratajczak, PhD; Anne Janin,(More)