Mária Filková

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BACKGROUND Identification of parameters for early diagnosis and treatment response would be beneficial for patients with early rheumatoid arthritis (ERA) to prevent ongoing joint damage. miRNAs have features of potential biomarkers, and an altered expression of miRNAs was shown in established rheumatoid arthritis (RA). OBJECTIVE To analyse RA associated(More)
OBJECTIVE Interleukin-35 (IL-35) is a heterodimeric member of the IL-12 family consisting of p35/IL-12a and EBI3/IL-27b subunits. Expressed in murine Treg cells, IL-35 controls inflammatory diseases in mouse models. However, human IL-35 is expressed in Teff cells rather than in Treg cells and is shown to be upregulated under inflammatory conditions. Our aim(More)
Resistin was originally described as an adipocyte-secreted peptide that induced insulin resistance in rodents. Increasing evidence indicates its important regulatory roles in various biological processes, including several inflammatory diseases. Further studies have shown that resistin in humans, in contrast to its production by adipocytes in mice, is(More)
Scientifi c interest in adipose tissue-derived peptides has increased dramatically in recent years.1 Several mediators known as adipo(cyto)kines were fi rst associated with the pathophysiology of obesity-related complications; however, a signifi cant role for adipokines such as leptin, adiponectin, resistin and visfatin in regulating immune responses and(More)
Filková, M; Lisková, M; Hulejová, H; Haluzík, M; Gatterová, J; Pavelková, A; Pavelka, K; Gay, S; Müller-Ladner, U; Senolt, L Filková, M; Lisková, M; Hulejová, H; Haluzík, M; Gatterová, J; Pavelková, A; Pavelka, K; Gay, S; Müller-Ladner, U; Senolt, L (2009). Increased serum adiponectin levels in female patients with erosive compared with non-erosive(More)
OBJECTIVE Fibrin deposits are characteristic of the synovial tissues in rheumatoid arthritis (RA). Once citrullinated, fibrin becomes an autoantigen and is thought to contribute in this way to perpetuate the disease. Our study aimed to analyse the responses of RA synovial fibroblasts (RASF) to native and citrullinated fibrin. METHODS The transcriptome(More)
Axial spondyloarthritis is a chronic inflammatory disease with the onset at a young age, and, if undiagnosed and untreated, it may result in permanent damage and lifelong disability. Rates of early diagnosis have improved, due in particular to the addition of magnetic resonance imaging into the diagnostic armamentaria; however, it is costly, not widely(More)
OBJECTIVES To study the association of systemic and local interleukin-35 (IL-35) levels in rheumatoid arthritis. METHODS 37 patients with treatment naïve early RA, 49 with established RA and 29 control patients with osteoarthritis (OA) were studied. Serum and paired synovial fluid samples were analysed for IL-35. Disease activity of RA patients was(More)
OBJECTIVES Prolactin (PRL) is a hormone with cytokine-like activities that has been demonstrated to be involved in immune responses. However, there are inconsistent results related to the role of PRL in rheumatoid arthritis (RA). Therefore, the aim of this study was to evaluate the levels of PRL in serum and synovial fluid in patients with RA and(More)
OBJECTIVE To evaluate circulating visfatin and its relationship with disease activity and serum lipids in patients with early, treatment-naïve rheumatoid arthritis (RA). METHODS Serum visfatin was measured in 40 patients with early RA before and after three months of treatment and in 30 age- and sex-matched healthy individuals. Disease activity was(More)