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Ceramide monohexosides (CMHs, cerebrosides) are glycosphingolipids composed of a hydrophobic ceramide linked to one sugar unit. In fungal cells, CMHs are very conserved molecules consisting of a ceramide moiety containing 9-methyl-4,8-sphingadienine in amidic linkage to 2-hydroxyoctadecanoic or 2-hydroxyhexadecanoic acids, and a carbohydrate portion(More)
Synthetic peptides with sequences identical to fragments of the constant region of different classes (IgG, IgM, IgA) of antibodies (Fc-peptides) exerted a fungicidal activity in vitro against pathogenic yeasts, such as Candida albicans, Candida glabrata, Cryptococcus neoformans, and Malassezia furfur, including caspofungin and triazole resistant strains.(More)
Symbols occupy a pivotal position between processes to be carried out and concepts to be thought about. They allow us both to d o mathematical problems and to think about mathematical relationships. In this presentation we consider the discontinuities that occur in the learning path taken by different students, leading to a divergence between conceptual and(More)
This paper begins by considering the cognitive mechanisms available to individuals which enable them to operate successfully in different parts of the mathematics curriculum. We base our theoretical development on fundamental cognitive activities, namely, perception of the world, action upon it and reflection on both perception and action. We see an(More)
Concepts of infinity usually arise by reflecting on finite experiences and imagining them extended to the infinite. This paper will refer to such personal conceptions as natural infinities. Research has shown that individuals' natural conceptions of infinity are 'labile and self-contradictory' (Fischbein et al., 1979, p. 31). The formal approach to(More)
BACKGROUND Costs of tuberculosis diagnosis and treatment may represent a significant burden for the poor and for the health system in resource-poor countries. OBJECTIVES The aim of this study was to analyze patients' costs of tuberculosis care and to estimate the incremental cost-effectiveness ratio (ICER) of the directly observed treatment (DOT) strategy(More)
BACKGROUND Latent tuberculosis infection (LTBI) is a reservoir for new TB cases. Isoniazid preventive therapy (IPT) reduces the risk of active TB by as much as 90%, but LTBI screening has limitations. Unlike tuberculin skin testing (TST), interferon-gamma release assays are not affected by BCG vaccination, and have been reported to be cost-effective in(More)
INTRODUCTION Cost effectiveness analyses (CEA) can provide useful information on how to invest limited funds, however they are less useful if different analysis of the same intervention provide unclear or contradictory results. The objective of our study was to conduct a systematic review of methodologic aspects of CEA that evaluate Interferon Gamma Release(More)
Changes in land use/land cover are a major driver of biodiversity change in the Mediterranean region. Understanding how animal populations respond to these landscape changes often requires using landscape mosaics as the unit of investigation, but few previous studies have measured both response and explanatory variables at the land mosaic level. Here, we(More)
It is well known that students and mathematicians have idiosyncratic beliefs about the real numbers. This research reveals confusions about rational numbers in undergraduates studying to be teachers. Earlier experiences of fractions and decimals in school (such as the long exposure to finite decimal expansions and the link between π and 22 7) lead to subtle(More)