Lyudmila I Buryachkovskaya

Learn More
A comparative study of hypotensive effects of binuclear forms of dinitrosyl iron complexes (DNICs) with glutathione, S-nitrosoglutathione (GS-NO) and sodium nitrite (NaNO(2)) on rats has been carried out. The latter appeared to be the least efficient, viz., mean arterial pressure (MAP) decreased by 10 and 30 mmHg at 25 and 100 μmoles/kg of NaNO(2). In(More)
In some patients with stable and unstable angina pectoris and in some donors without clinical manifestations of cardiovascular diseases and other pathologies, spontaneous platelet aggregation was completely suppressed by glycoprotein IIb-IIIa antagonists blocking the interaction of this glycoprotein with fibrinogen. Antibodies inhibiting binding of(More)
In the generalized form of meningococcal infection toxemia is one of the factors which disturbs hemostasis and promotes thrombohemorrhagic complications. Definite views on the origin of these complications have now been formed. Disturbance of the integrity of the vessel wall [4, 5, 14] and injury to the blood cells [6, 13] under the influence of(More)
The toxemia which accompanies infectious diseases is one factor leading to activation, and sometimes to injury of platelets. Under these circumstances biologically active substances (serotonin, ADP, platelet factors 3 and 4, etc.) which play an essential role in hemostasis and in the microcirculation are secreted from the platelets. It has been shown that(More)
The function of granules in rabbit platelets participating in the reversible endocytosis reaction was investigated. The reaction is induced by two types of inducers: proteolytic enzymes and compounds accumulating inside the granules (biogenic amines, dyes, anesthetics, phenothiazines). Heparin inhibits exocytosis induced by thrombin. In the case of(More)
Effects of H2O2 on platelet aggregation were estimated in vitro in the presence and absence of inductors (ADP, serotonin, TRAP) and native and modified catalase. Dose-dependent effect of H2O2 (50 μM or more) was investigated in a pathophysiological concentration of 300 μM inducing platelet aggregation. H2O2 modulated aggregation induced by ADP, serotonin,(More)
  • 1