Lyubov Ushakova

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The ability to group stimuli into perceptual categories is essential for efficient interaction with the environment. Discrete dynamics that emerge in brain networks are believed to be the neuronal correlate of category formation. Observations of such dynamics have recently been made; however, it is still unresolved if they actually match perceptual(More)
Long-lasting changes in synaptic connections induced by relevant experiences are believed to represent the physical correlate of memories. Here, we combined chronic in vivo two-photon imaging of dendritic spines with auditory-cued classical conditioning to test if the formation of a fear memory is associated with structural changes of synapses in the mouse(More)
The cells that are responsible for detecting magnetic fields in animals remain undiscovered. Previous studies have proposed that pigeons employ a magnetic sense system that consists of six bilateral patches of magnetite containing dendrites located in the rostral subepidermis of the upper beak. We have challenged this hypothesis arguing that clusters of(More)
Hair cells reside in specialized epithelia in the inner ear of vertebrates, mediating the detection of sound, motion, and gravity. The transduction of these stimuli into a neuronal impulse requires the deflection of stereocilia, which are stabilized by the actin-rich cuticular plate. Recent electrophysiological studies have implicated the vestibular system(More)
The cellular basis of the magnetic sense remains an unsolved scientific mystery. One theory that aims to explain how animals detect the magnetic field is the magnetite hypothesis. It argues that intracellular crystals of the iron oxide magnetite (Fe3O4) are coupled to mechanosensitive channels that elicit neuronal activity in specialized sensory cells.(More)
Microtubules play a crucial role in the generation, migration and differentiation of nascent neurons in the developing vertebrate brain. Mutations in the constituents of microtubules, the tubulins, are known to cause an array of neurological disorders, including lissencephaly, polymicrogyria and microcephaly. In this study we explore the genetic and(More)
Corticosteroids, especially dexamethasone (DM), play an important role in eye therapy [I]. DM is used in the form of a 0.1% suspension or 0 .050.1% solutions. Although DM is now produced in Russia, no domestic ophthalmologic preparations have been developed until recently. The purpose of this work was to prepare DM-based eye drops using the commercially(More)
Possessing low toxicity, ibuprofen occupies a special position among nonsteroidal antiinflammatory drugs used for the treatment of rheumatic disorders: presently, this drug is administered in both internal and external forms. In Russia, registered external forms of ibuprofen include ibutop gel and dolgit cream (Germany), the latter being most widely known.(More)
In view of the wide use of butoconazole nitrate in practical gynecology, a method for determining this drug in the blood of experimental animals has been developed based on capillary electrophoresis. Samples were prepared using sedimentation of plasma proteins by acetonitrile. The separation was carried out at 27°C in a quartz capillary (75 μm diameter, 65(More)
To meet the growing interest of the Russian pharmaceutical companies in butadion ointment, which has been used for a long time and has become popular in this country, we have studied the possibility of producing this medicinal form in Russia using available auxiliary components. The purpose of this investigation was to search for a possible base, prepare an(More)