Lyubomira Ivanova

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Neuronal mechanisms of description of local properties of visual object light-shadow surfaces are studied. Earlier we have shown the cat lateral geniculate body (LGB) neurons to have sensitivity to the value and direction of brightness vector in loci of object light-shadow surfaces. Further study of properties of orientational selectivity (OS) of these(More)
The number of γH2AX foci per nucleus is an accepted measure of the number of DNA double-strand breaks in single cells. One of the experimental techniques for γH2AX detection in cultured cells is immunofluorescent labelling of γH2AX and nuclei followed by microscopy imaging and analysis. In this study, we present the algorithm FoCo for reliable and robust(More)
Excessive DNA damage can induce an irreversible cell cycle arrest, called senescence, which is generally perceived as an important tumour-suppressor mechanism. However, it is unclear how cells decide whether to senesce or not after DNA damage. By combining experimental data with a parameterized mathematical model we elucidate this cell fate decision at the(More)
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