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- Lynne W. Elmore, Catherine W Rehder, +4 authors Shawn E. Holt
- The Journal of biological chemistry
- 2002
Direct experimental evidence implicates telomere erosion as a primary cause of cellular senescence. Using a well characterized model system for breast cancer, we define here the molecular and… (More)
- David Gewirtz, Shawn E. Holt, Lynne W. Elmore
- Biochemical pharmacology
- 2008
Treatment of malignancies with chemotherapeutic drugs and/or radiotherapy is designed to eliminate the disease by depriving the tumor cell of its reproductive potential. Frequently, the desired… (More)
- K. R. Jones, Lynne W. Elmore, +4 authors David Gewirtz
- International journal of radiation biology
- 2005
Ionizing radiation has been reported to promote accelerated or premature senescence in both normal and tumour cell lines. The current studies were designed to characterize the accelerated senescence… (More)
- Lynne W. Elmore, Xu Di, Catherine I. Dumur, Shawn E. Holt, David Gewirtz
- Clinical cancer research : an official journal of…
- 2005
PURPOSE
The purpose of this study is to define the mechanistic basis for recovery of proliferative capacity in breast tumor cells after chemotherapy. Here, we test the hypothesis that evasion of… (More)
- Lynne W. Elmore, Amanda Hancock, +6 authors C. C. Harris
- Proceedings of the National Academy of Sciences…
- 1997
We have reported previously that the hepatitis B virus oncoprotein, HBx, can bind to the C terminus of p53 and inhibit several critical p53-mediated cellular processes, including DNA… (More)
- Michael Francis, Patrick C Sachs, Lynne W. Elmore, Shawn E. Holt
- Organogenesis
- 2010
Isolation of adipose-derived stem cells (ASCs) typically involves 8+ hours of intense effort, requiring specialized equipment and reagents. Here, we present an improved technique for isolating viable… (More)
- Alison J Montpetit, Areej A Alhareeri, +8 authors Colleen K. Jackson-Cook
- Nursing research
- 2014
BACKGROUND
The exciting discovery that telomere shortening is associated with many health conditions and that telomere lengths can be altered in response to social and environmental exposures has… (More)
- Heidi L Forsythe, J. L. Jarvis, Jennifer Turner, Lynne W. Elmore, Samantha E Holt
- The Journal of biological chemistry
- 2001
The ribonucleoprotein telomerase holoenzyme is minimally composed of a catalytic subunit, hTERT, and its associated template RNA component, hTR. We have previously found two additional components of… (More)
- Lynne W. Elmore, Michelle W Norris, +4 authors Shawn E. Holt
- Experimental biology and medicine
- 2008
Telomerase plays a primary role in the maintenance of telomeres in immortal, germ, and tumor cells in humans but is lacking in most somatic cells and tissues. However, many species, including fish… (More)
We find that cells infected with wild-type group C human adenoviruses are not killed by exposure to tumor necrosis factor (TNF), but cells infected with adenoviruses that delete the E3 transcription… (More)