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OBJECTIVE The aim was to assess the relationship between adipokines, including interleukin (IL)-6, leptin, and adiponectin, with development of type 2 diabetes and assess the role of obesity and insulin resistance in these relationships. RESEARCH DESIGN AND METHODS We conducted a prospective study of 3,599 nondiabetic men aged 60-79 years and followed up(More)
BACKGROUND The nature and contribution of different pregnancy-related complications to future cardiovascular disease (CVD) and its risk factors and the mechanisms underlying these associations remain unclear. METHODS AND RESULTS We studied associations of pregnancy diabetes mellitus, hypertensive disorders of pregnancy, preterm delivery, and size for(More)
CONTEXT Adiponectin levels appear weakly linked to incident vascular disease, but the high molecular weight (HMW) fraction may be more relevant. OBJECTIVE Our objective was to test whether HMW adiponectin, the key biologically active fraction, is linked to incident coronary heart disease (CHD) events. DESIGN, PARTICIPANTS, AND MAIN OUTCOME MEASURES: We(More)
OBJECTIVES To examine the prospective associations between body mass index (BMI), waist circumference, and fat mass in childhood and cardiovascular risk factors at age 15-16. DESIGN Prospective cohort study. SETTING Avon Longitudinal Study of Parents and Children. PARTICIPANTS 5235 children aged 9-12 at start of study. Main exposures BMI, waist(More)
Men with AS (ankylosing spondylitis) are at elevated risk for CHD (coronary heart disease) but information on risk factors is sparse. We compared a range of conventional and novel risk factors in men with AS in comparison with healthy controls and, in particular, determined the influence of systemic inflammation. Twenty-seven men with confirmed AS and 19(More)
BACKGROUND There is uncertainty about the association between circulating concentrations of adiponectin and coronary heart disease (CHD) risk. We report new data from a prospective study in the context of a meta-analysis of previously published prospective studies. METHODS AND RESULTS We measured baseline adiponectin levels in stored serum samples of 589(More)
OBJECTIVE To conduct a robust, double-blind, placebo-controlled study examining the effects of tumor necrosis factor (TNF) modulation on concentrations of traditional and novel cardiovascular disease risk factors in patients with an inflammatory condition. METHODS In this double-blind study, 127 patients with psoriatic arthritis (PsA) and active psoriasis(More)
BACKGROUND Adiponectin is an anti-inflammatory and potentially antiatherogenic molecule. Some recent reports suggest that tumour necrosis factor alpha (TNFalpha) blockade therapy increases circulating adiponectin levels, but data are sparse and inconsistent. METHODS Data from a double-blind placebo controlled study of onercept in 126 patients with(More)
OBJECTIVE To examine the association of insulin-like-growth factor 1 (IGF-1) with coronary heart disease (CHD) in women. METHODS Prospective (4 year) case-control study nested within the British Women's Heart and Health Study. With 167 cases and 333 controls. Serum IGF-1 concentrations (on serum stored at -80 degrees C for a median of 4 years) were(More)
Preeclampsia is characterized by hypertension, dyslipidemia, and increased systemic inflammatory response and has been associated with an increased maternal risk of cardiovascular disease later in life. Low-grade chronic inflammation is a risk factor for cardiovascular disease. This study examined changes in inflammatory markers prospectively during(More)