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Nerve growth factor (NGF) stimulates expression of the low affinity neurotrophin receptor p75NGFR mRNA in primary cultures of neonatal rat cortical type I astrocytes. Nerve growth factor treatment altered glial morphology in glial fibrillary acidic protein positive (GFAP+) cell cultures derived from newborn (P0) and 3-day-old (P3) rat pups. When P0- or(More)
Programmed cell death, the intrinsic form of apoptosis, plays an integral role in those neurodegenerative events associated with age-related neuropathology. Neurotrophins (NTs), such as nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and NT-3, are required for survival of certain neurons, and thus their clinical use to counteract age-(More)
OBJECTIVE To examine the time course of anxiety and depressive symptoms over a three year period after amputation. DESIGN AND SETTINGS A prospective study in inpatients admitted to a rehabilitation ward after lower limb amputation. SUBJECTS Successive admissions over a one-year period of whom 68 were alive at follow-up, 2-3 years later. INTERVENTIONS(More)
The level of recC gene expression has been analysed using Mud(bla lac) fusions to the recC promoter. The constitutive level of expression is very low and remains so even under SOS inducing conditions. The recC gene product has been amplified by harnessing the gene to the phage lambda leftward promoter in a plasmid. From cells harbouring this plasmid, RecC(More)
Using a quantitative reverse transcription-polymerase chain reaction (RT-PCR) we have investigated the expression of the neurotrophin receptors p75NGFR, trkA, and trkB mRNAs in cultures of rat pup type I astrocytes and in the C6 rat glioma cell line. All three neurotrophin receptor mRNAs are expressed in both C6 cells and in type I astrocytic cultures.(More)
Nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) are members of the family of neurotrophins that are highly expressed in the adult hippocampus, and to a lesser extent, in the cerebral cortex and olfactory bulb. Since neuronal expression of neutrophins is controlled by some neurotransmitters and there is a(More)
The Escherichia coli RecB protein, normally synthesized in low amounts, has been amplified by linkage of the recB gene to the phage lambda leftward promoter in an expression plasmid. From strains harboring this plasmid, RecB protein has been purified to homogeneity by a simple procedure which includes affinity chromatography on a column of RecC protein(More)
In the absence of responding, pigeons were shocked under a variable-time schedule. Responses on either of two keys occasionally produced one minute of shock-free time. That is, pigeons' key pecks were reinforced with shock-free time under concurrent variable-interval schedules. The relative frequency of access to the one-minute shock-free periods was(More)
  • L Hutton
  • 1984
Oleothorax is a method of therapy for pulmonary tuberculosis that was largely abandoned in the 1950s. Its purpose was to cause collapse of the adjacent lung by mechanical means. In the absence of either reactivation of tuberculosis or the development of an empyema, an oleothorax may expand to such an extent as to cause respiratory distress and require(More)