Lynne Hobson

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Chromosomal fragile site FRA16D and DNA instability in cancer.

Marie E. Mangelsdorf, Karin Ried, +8 authors Rhodri Richards
Cancer research
2000

It has been proposed that common aphidicolin-inducible fragile sites, in general, predispose to specific chromosomal breakage associated with deletion, amplification, and/or translocation in certain… (More)

Common chromosomal fragile site FRA16D sequence: identification of the FOR gene spanning FRA16D and homozygous deletions and translocation breakpoints in cancer cells.

Karin Ried, Merran Finnis, +9 authors Rhodri Richards
Human molecular genetics
2000

Fluorescence in situ hybridization of a tile path of DNA subclones has previously enabled the cyto-genetic definition of the minimal DNA sequence which spans the FRA16D common chromosomal fragile… (More)

Human Chromosomal Fragile Site FRA16B Is an Amplified AT-Rich Minisatellite Repeat

Sui huai Yu, Marie E. Mangelsdorf, +8 authors Robert I. Richards
Cell
1997

Fragile sites are nonstaining gaps in chromosomes induced by specific tissue culture conditions. They vary both in population frequency and in the culture conditions required for induction.… (More)

Cure of human carcinoma xenografts by a single dose of pretargeted yttrium-90 with negligible toxicity.

Donald B. Axworthy, Jessica Reno, +7 authors Alan R. Fritzberg
Proceedings of the National Academy of Sciences…
2000

A covalent conjugate (NR-LU-10/SA) was prepared between streptavidin (SA) and NR-LU-10, a mAb that binds an antigen expressed on the surface of most human carcinomas. NR-LU-10/SA was injected into… (More)

Persistent of respiratory syncytial virus in human dendritic cells and influence of nitric oxide.

Lynne Hobson, Mark L Everard
Clinical and experimental immunology
2008

The annual epidemics of respiratory syncytial virus (RSV) infection are probably explained by poor herd immunity and the existence of a dormant reservoir of virus that is activated by an unknown… (More)

FRA10B structure reveals common elements in repeat expansion and chromosomal fragile site genesis.

David R Hewett, Oliva Handt, +7 authors Rhodri Richards
Molecular cell
1998

A common mechanism for chromosomal fragile site genesis is not yet apparent. Folate-sensitive fragile sites are expanded p(CCG)n repeats that arise from longer normal alleles. Distamycin A or… (More)

Differentiation and immune function of human dendritic cells following infection by respiratory syncytial virus.

A. Jones, Inge Morton, Lynne Hobson, Gareth J S Evans, Mark L Everard
Clinical and experimental immunology
2006

RSV causes annual epidemics of bronchiolitis in winter months resulting in the hospitalization of many infants and the elderly. Dendritic cells (DCs) play a pivotal role in coordinating immune… (More)

Common chromosomal fragile site FRA16D mutation in cancer cells.

Merran Finnis, Sonia Dayan, +7 authors Robert I. Richards
Human molecular genetics
2005

Neither the molecular basis for common fragile site DNA instability nor the contribution of this form of chromosomal instability to cancer is clearly understood. Fragile site FRA16D (16q23.2) is… (More)

Defects in tRNA Anticodon Loop 2'-O-Methylation Are Implicated in Nonsyndromic X-Linked Intellectual Disability due to Mutations in FTSJ1.

Michael P. Guy, Marie Shaw, +6 authors Eric M. Phizicky
Human mutation
2015

tRNA modifications are crucial for efficient and accurate protein synthesis, and modification defects are frequently associated with disease. Yeast trm7Δ mutants grow poorly due to lack of… (More)

A non-coding variant in the 5ʹ UTR of DLG3 attenuates protein translation to cause non-syndromic intellectual disability

Raman Kumar, Thuong G. Van Ha, +10 authors Jozef Gécz
European Journal of Human Genetics
2016

Intellectual disability (ID) is a clinically complex and heterogeneous disorder, which has variable severity and may be associated with additional dysmorphic, metabolic, neuromuscular or psychiatric… (More)

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