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In rodents, the orphan G protein-coupled receptor, Gpr88, is highly expressed in brain regions implicated in the pathophysiology of and is modulated by treatments for schizophrenia. We compared striatal function of Gpr88 knockout mice (Gpr88KOs) to wild-type mice using molecular, neurochemical and behavioral tests. Gpr88KOs lacked expression of Gpr88 in(More)
GPR26 and GPR78 are orphan GPCRs (oGPCRs) that share 51% amino acid sequence identity and are widely expressed in selected tissues of the human brain as well as the developing and adult mouse brain. Investigation of the functional activity of GPR26 and GPR78 via expression in HEK293 cells showed that both proteins are constitutively active and coupled to(More)
Giardia duodenalis and Enterocytozoon bieneusi are two common protozoa that parasitize the intestinal epithelium of animals and humans. Calves have been identified as important reservoirs of these two pathogens, but limited data is available for these two pathogens in calves in China. In the present study, the prevalence and assemblages/genotypes of both(More)
OBJECTIVE Vascular endothelial growth factor (VEGF) induces angiogenesis by stimulating reactive oxygen species (ROS) production primarily through the VEGF receptor-2 (VEGFR2). One of the initial responses in established vessels to stimulate angiogenesis is loss of vascular endothelial (VE)-cadherin-based cell-cell adhesions; however, little is known about(More)
Neuropathic pain resulting from nerve lesions or dysfunction represents one of the most challenging neurological diseases to treat. A better understanding of the molecular mechanisms responsible for causing these maladaptive responses can help develop novel therapeutic strategies and biomarkers for neuropathic pain. We performed a miRNA expression profiling(More)
This report describes the identification and characterization of the murine orphan GPCR, Gpr101. Both human and murine genes were localized to chromosome X. Similar to its human ortholog, murine Gpr101 mRNA was detected predominantly in the brain within discrete nuclei. A knowledge-restricted hidden Markov model-based algorithm, capable of accurately(More)
Hydroponic experiments were conducted to investigate the effects of nitrogen forms on nitric oxide accumulation and glycinebetaine (GB) metabolism under osmotic stress (OS) simulated by the addition of polyethylene glycol (PEG-6000) to two maize (Zea mays L.) cultivars Zhengdan 958 (ZD958; drought-tolerant) and Jundan 20 (JD20; drought-sensitive). OS led to(More)
Keywords: System dynamics model Energy consumption CO2 emissions STELLA a b s t r a c t It is clear that city must be part of the solution if an urbanizing world is to grapple successfully with ecological challenges such as energy depletion and climate change. A system dynamics model was developed in this study using STELLA platform to model the energy(More)
Computer-aided prototyping shows promise that one system under development frees designers from implementation details by executing specifications via reusable components. Ada is first choice for constructing such reusable object-oriented components because Ada95 is the only international standard programming language that supports object-oriented real-time(More)