Lynn Walton

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Milrinone and dobutamine are positive inotropic agents with beneficial hemodynamic effects in patients with congestive heart failure. This study was undertaken to compare the effects of intravenous milrinone and dobutamine in patients with stable New York Heart Association class III or IV congestive heart failure and to test the hypothesis that intravenous(More)
PURPOSE A dose-escalation study was conducted to determine the maximum-tolerated dose (MTD) and dose-limiting toxicities (DLTs) of cyclophosphamide (CY) in combination with granulocyte colony-stimulating factor (G-CSF0 and doxorubicin (DOX) given every 2 weeks for eight cycles as outpatient adjuvant therapy for node-positive breast cancer. A pilot study to(More)
Regional delivery of iododeoxyuridine (IdUrd) to patients with colorectal liver metastases was examined in a phase I study. The maximum-tolerated intraarterial (IA) dose (MTD) was 1,333 mg/m2/d administered continuously for 14 days. The dose-limiting toxicity was thrombocytopenia. Thrombocytopenia and leukopenia were correlated with the amount of IdUrd(More)
To assess the potential efficacy of trimethoprim-sulfamethoxazole (TMP-SMX) against serious enterococcal infections, we used a rat enterococcal endocarditis model comparing TMP-SMX therapy (500 mg of TMP plus 2,500 mg of SMX per kg of body weight per day given every 8 h by intragastric gavage) with intravenous ampicillin therapy (1,000 mg/kg per day).(More)
The cardiotonic activity of milrinone (Win 47203), a potent analogue of amrinone, was demonstrated in isolated guinea pig, cat, rabbit, rat, and hamster atria and papillary muscles. Milrinone, in concentrations of 0.1-300 micrograms/ml, caused concentration-dependent increases in guinea pig papillary muscle and atrial developed tension with minimal(More)
BACKGROUND Intraoperative radiotherapy (IORT) is promising approach that is being tested in randomised clinical trials. In the Targit (TARGeted Intraopeartive radioTherapy) trial IORT can be delivered at the time of primary surgery or as a second procedure. Patients prefer the single procedure of intraoperative radiotherapy even if it is under general(More)
Occipitofrontal head circumference (OFC), using tape, and calibrated scale and cranial volumes, using styrofoam plastic cast, were measured in nine preterm and 13 term infants. Term infants had a mean +/- S.E. gestation of 40 +/- 0.2 wk and a mean +/- S.E. birth weight of 3461 +/- 108 g. Preterm infants had a mean +/- S.E. gestation of 30.5 +/- 1.4 wk and a(More)