Lynn W. Opare-Addo

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It is thought that differentiation of beta-cell precursors into mature cells is largely autonomous, but under certain conditions differentiation can be modified by external factors. The factors that modify beta-cell differentiation have not been identified. In this study, we tested whether adult islet cells can affect the differentiation process in mouse(More)
OBJECTIVE β-Cell and islet endothelial cell destruction occurs during the progression of type 1 diabetes, but, paradoxically, β-cell proliferation is increased during this period. Altered glucose tolerance may affect β-cell mass and its association with endothelial cells. Our objective was to study the effects of glucose and inflammation on islet(More)
OBJECTIVE—b-Cell and islet endothelial cell destruction occurs during the progression of type 1 diabetes, but, paradoxically, b-cell proliferation is increased during this period. Altered glucose tolerance may affect b-cell mass and its association with endothelial cells. Our objective was to study the effects of glucose and inflammation on islet(More)
Inflammatory cytokines are involved in autoimmune diabetes: among the most prominent is interleukin (IL)-1β. We postulated that blockade of IL-1β would modulate the effects of anti-CD3 monoclonal antibody (mAb) in treating diabetes in NOD mice. To test this, we treated hyperglycemic NOD mice with F(ab')(2) fragments of anti-CD3 mAb with or without IL-1(More)
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