Lynn M Matrisian

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Expansion of myeloid immune suppressor Gr+CD11b+ cells in tumor-bearing host directly promotes tumor angiogenesis.

Li Yang, Laura M. Debusk, +6 authors Pengnian Charles Lin
Cancer cell
2004

We demonstrate a novel tumor-promoting role of myeloid immune suppressor Gr+CD11b+ cells, which are evident in cancer patients and tumor-bearing animals. These cells constitute approximately 5% of… (More)

Metalloproteinases and their inhibitors in matrix remodeling.

Lynn M Matrisian
Trends in genetics : TIG
1990

The matrix metalloproteinases are a tightly regulated family of enzymes that degrade extracellular matrix and basement membrane components. Recent evidence suggests that these proteases and their… (More)

Changing views of the role of matrix metalloproteinases in metastasis.

A. F. Chambers, Lynn M Matrisian
Journal of the National Cancer Institute
1997

Metastatic spread of cancer continues to be the greatest barrier to cancer cure. Understanding the molecular mechanisms of metastasis is crucial for the design and effective use of novel therapeutic… (More)

Matrix metalloproteinase inhibitors and cancer: trials and tribulations.

Lisa M. Coussens, Barbara Fingleton, Lynn M Matrisian
Science
2002

For at least 30 years, matrix metalloproteinases (MMPs) have been heralded as promising targets for cancer therapy on the basis of their massive up-regulation in malignant tissues and their unique… (More)

Release of an invasion promoter E-cadherin fragment by matrilysin and stromelysin-1.

Veerle Noë, Barbara Fingleton, +6 authors Marc Mareel
Journal of cell science
2001

The function of many transmembrane molecules can be altered by cleavage and subsequent release of their ectodomains. We have investigated ectodomain cleavage of the cell-cell adhesion and… (More)

Projecting cancer incidence and deaths to 2030: the unexpected burden of thyroid, liver, and pancreas cancers in the United States.

Lola Rahib, Benjamin D. Smith, Rhonda Aizenberg, Allison B Rosenzweig, Julie M. Fleshman, Lynn M Matrisian
Cancer research
2014

Cancer incidence and deaths in the United States were projected for the most common cancer types for the years 2020 and 2030 based on changing demographics and the average annual percentage changes… (More)

Matrix metalloproteinases as mediators of reproductive function.

Diana L Hulboy, Lydia Rudolph, Lynn M Matrisian
Molecular human reproduction
1997

The organs of the adult reproductive system can undergo extensive remodelling, experiencing rapid changes in tissue mass and function. Much of this matrix remodelling is attributed to the action of… (More)

Matrix metalloproteinases: they're not just for matrix anymore!

Lisa J Mccawley, Lynn M Matrisian
Current opinion in cell biology
2001

The matrix metalloproteinases (MMPs) have been viewed as bulldozers, destroying the extracellular matrix to permit normal remodeling and contribute to pathological tissue destruction and tumor cell… (More)

Matrix metalloproteinases: biologic activity and clinical implications.

Amy R. Nelson, Barbara Fingleton, Mace L. Rothenberg, Lynn M Matrisian
Journal of clinical oncology : official journal…
2000

Tumor progression is a complex, multistage process by which a normal cell undergoes genetic changes that result in phenotypic alterations and the acquisition of the ability to spread and colonize… (More)

Abrogation of TGF beta signaling in mammary carcinomas recruits Gr-1+CD11b+ myeloid cells that promote metastasis.

Li Yang, Jianhua Huang, +8 authors Harold L. Moses
Cancer cell
2008

Aberrant TGFbeta signaling is common in human cancers and contributes to tumor metastasis. Here, we demonstrate that Gr-1+CD11b+ myeloid cells are recruited into mammary carcinomas with type II TGF… (More)

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