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PURPOSE To determine a microsomal scaling factor for human liver suitable for prediction of in vivo drug clearance from in vitro data and to explore the role of inter-liver variability in this factor on the reported underprediction from microsomal parameters. METHODS Cytochrome P450 (henceforth P450) content in whole homogenates and microsomes from 38(More)
To explain the cause of axial rotation in a scoliotic vertebral column, the influence of the gravitation force on a spine with a C-scoliosis has been investigated by means of a mechanical model. In this model the gravitation force takes hold of the three-dimensionally curved vertebral column eccentrically. From these reflections it appears that the axial(More)
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