Lynn L. Stoll

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Enkephalins are opioid peptides that are found at high levels in the brain and endocrine tissues. Studies have shown that enkephalins play an important role in behavior, pain, cardiac function, cellular growth, immunity, and ischemic tolerance. Our global hypothesis is that enkephalins are released from non-neuronal tissues in response to brief ischemia or(More)
BACKGROUND Bacterial endotoxin, long recognized as a potent pro-inflammatory mediator in acute infectious processes, has more recently been identified as a risk factor for atherosclerosis and other cardiovascular diseases. When endotoxin enters the bloodstream, one of the first cells activated is the circulating monocyte, which exhibits a wide range of(More)
BACKGROUND Recruitment of macrophage precursors to the adventitia plays a key role in the pathogenesis of abdominal aortic aneurysms (AAAs), but molecular mechanisms remain undefined. The innate immune signaling molecule CD14 was reported to be upregulated in adventitial macrophages in a murine model of AAA and in monocytes cocultured with aortic(More)
Surfactant protein D (SP-D) is a constituent of the innate immune system that plays a role in host defense against lung pathogens and in modulating inflammatory responses. While SP-D has been detected in extra-pulmonary tissues, little is known about its expression and function in the vasculature. Immunostaining of human coronary artery tissue sections(More)
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