Lynn E. Fletcher

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BACKGROUND We have compared mutation analysis by DNA sequencing and Amplification Refractory Mutation System™ (ARMS™) for their ability to detect mutations in clinical biopsy specimens. METHODS We have evaluated five real-time ARMS assays: BRAF 1799T>A, [this includes V600E and V600K] and NRAS 182A>G [Q61R] and 181C>A [Q61K] in melanoma, EGFR 2573T>G(More)
Objective To assess the effectiveness of antibiotic treatment of women with symptoms of urinary tract infection but negative urine dipstick testing. Design Prospective, double blind, randomised, placebo controlled trial. Setting Primary care, among a randomly selected group of general practitioners in Christchurch, New Zealand. Participants 59 women aged(More)
OBJECTIVES To compare the efficacy, safety, and acceptability of treatment with intravenous antibiotics for cellulitis at home and in hospital. DESIGN Prospective randomised controlled trial. SETTING Christchurch, New Zealand. PARTICIPANTS 200 patients presenting or referred to the only emergency department in Christchurch who were thought to require(More)
For any arthropod, molting is a risky endeavor; it leaves an organism vulnerable until its new cuticle hardens. In some social organisms, the safest place for an individual to molt may be within their group. Here I present preliminary observations of a potential signaling behavior associated with molting in the gregarious larvae of the Australian sawfly,(More)
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