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Arabidopsis fusca mutants display striking purple coloration due to anthocyanin accumulation in their cotyledons. We describe six recessive fusca mutants isolated from Agrobacterium-transformed Arabidopsis families. These mutants first become defective during embryogenesis and exhibit limited seedling development. Double mutant constructs revealed that(More)
Shoot architecture and flowering time in angiosperms depend on the balanced expression of a large number of flowering time and flower meristem identity genes. Loss-of-function mutations in the Arabidopsis EMBRYONIC FLOWER (EMF) genes cause Arabidopsis to eliminate rosette shoot growth and transform the apical meristem from indeterminate to determinate(More)
Mutations in EMBRYONIC FLOWER (EMF) genes EMF1 and EMF2 abolish rosette development, and the mutants produce either a much reduced inflorescence or a transformed flower. These mutant characteristics suggest a repressive effect of EMF activities on reproductive development. To investigate the role of EMF genes in regulating reproductive development, we(More)
Macrophage activation by IFN-gamma results in a cascade of gene expression. To identify genes activated in mouse peritoneal macrophages by IFN-gamma, we created a cDNA subtraction library of IFN-gamma-induced genes. We have isolated from this subtraction library a novel cDNA clone, called Mg21, whose mRNA is absent in unstimulated mouse peritoneal(More)
Expression of major histocompatibility complex (MHC) class II molecules and ability to present antigen to T lymphocytes is acquired upon activation of the macrophage by interferon-gamma (IFN-gamma). Little information is available concerning immune regulation of protease gene expression in mouse macrophages. We have isolated a cDNA clone for cathepsin H, a(More)
To identify genes induced in mouse macrophages by IFN-gamma, a cDNA subtraction library of IFN-gamma-induced genes was screened. One of the clones, 36F2, was identified by DNA sequencing as the FIBLP gene. The FIBLP (fibrinogen-like protein) gene is a T-lymphocyte-specific gene that is expressed in mouse cytotoxic T lymphocytes but not in helper T(More)
Molecular genetic analysis has demonstrated that recombination in the mouse H-2 major histocompatibility complex is not random but occurs frequently at specific sites. These recombination hot spots have been mapped between the H-2K and A~2 genes (Steinmetz et al. 1986, Uematsu et al. 1986, 1988), and within the E~ (Steinmetz et al. 1982, Kobori et al. 1984,(More)
Recombinant mouse strains with crossovers in the H-2 major histocompatibility complex (MHC) that have been studied by restriction fragment length polymorphism (RFLP) analysis and DNA sequencing have crossovers in the segment between the H-2K and E~ genes. Over 30 recombinant strains have been found to contain crossovers in the E~ gene (Steinmetz et al.(More)
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