Lynn C. Yeoman

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The present study was undertaken to provide information on the presence and frequency of satellite nucleoli in cells with increased nucleolar biosynthetic activity. The number of hepatocytes containing satellite nucleoli was analyzed in rat liver, regenerating liver 18 h after partial hepatectomy and in Novikoff hepatoma ascites cells. In comparison with(More)
The cytosolic proteins and phosphoproteins of a mitomycin Csensitive cell line were examined as progressively greater doses of mitomycin C were administered over a period of 44 weeks. Resistance of the human colon carcinoma cell line increased from a 50% inhibitory concentration of 1 to 6 ¿¿M over this time period. Changes in cytosolic protein patterns(More)
In earlier studies, the nucleolar levels of protein A24 were found to be markedly decreased in the nucleolar hypertrophy induced by thioacetamide or during liver regeneration (Ballal, N. R., Goldknopf, I. L., Goldberg, D. A., and Busch, H. (1974) Life Sci. 14, 1835-1845; Ballal, N. R., Kang, Y.-J., Olson, M. O.-J., and Busch, H. J. Biol. Chem. 250,(More)
1. Highly purified arginineand lysine-rich histone was maleylated and then hydrolyzed with trypsin. A large amount of precipitate approximating 35% of the histone appeared during the demaleylation procedure. The precipitate was separated into four fractions on a Sephadex G-50 column and one fraction, tryptic peptide II from the maleylated histone, was found(More)
The acid-soluble nuclear proteins of regenerating and thioacetamide-treated rat livers as well as the Morris 9618A hepatoma and the Walker 256 carcinosarcoma were ex tracted from citric acid-isolated nuclei with 0.4 N H2SO4. The nuclear extracts were analyzed by two-dimensional polyacrylamide gel electrophoresis. Although most of the protein spots were(More)
Antisera to nucleoli of Novikoff hepatoma ascites and normal rat liver cells were produced in rabbits by injection of whole, isolated nucleoli. These antisera have been used to compare the nucleolar antigens that were partially fractionated by differential solubilization from nucleoli. Fourteen antigens were detected by these antisera; ten of these antigens(More)
TO determine whether red blood cell-mediated microinjection of antibodies can be used to study nuclear protein localization and function, we microinjected antibodies that have been shown to react specifically with nucleolar acidic phosphoprotein C23 into Walker 256 cells. The intracellular distribution of microinjected anti-C23 antibodies and preimmune(More)
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