Lyne Lalonde

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BACKGROUND Enoxaparin dosage for obese patients and patients with renal impairment remains controversial. OBJECTIVE To compare anti-factor Xa activity (anti-Xa) among obese and renal impairment patients to patients with healthy weight and adequate renal function. DESIGN Open, prospective, nonrandomized clinical trial. SETTING A major community(More)
A cross-sectional survey (n = 878) was conducted to compare the psychometric properties of three preference-based and one nonpreference-based health-related quality of life measures among healthy subjects with and without treatment for dyslipidemia and/or hypertension and patients with coronary heart disease (CHD). All measures were stable over a 3 to 6(More)
BACKGROUND Cardiovascular diseases (CVD) represent a heavy economic burden on individuals, health services, and society. Low adherence to antihypertensive (AH) agents is acknowledged as a major contributor to the lack of blood pressure control, and may have a significant impact on clinical outcomes and healthcare costs. OBJECTIVES To evaluate the impact(More)
BACKGROUND Evidence from meta-analyses shows that statin therapy reduces all-cause mortality and nonhemorrhagic strokes. Nonadherence to statins may reduce this protective effect. The association between statin adherence and incidence of cerebrovascular disease remains unexplored outside the context of clinical trials. OBJECTIVE To evaluate the impact of(More)
BACKGROUND AND PURPOSE The benefits of antihypertensive (AH) drugs on the risks of major cardiovascular outcomes have been demonstrated in clinical trials. However, approximately half of hypertensive patients do not adhere well to their prescribed AH therapy in actual practice. The purpose of this study was to assess the impact of adherence to AH agents on(More)
BACKGROUND Primary care providers' knowledge, attitudes and beliefs (KAB) regarding chronic noncancer pain (CNCP) are a barrier to optimal management. OBJECTIVES To evaluate and identify the determinants of the KAB of primary care physicians and pharmacists, and to document clinician preferences regarding the content and format of a continuing education(More)
UNLABELLED Given the increasing prevalence of multimorbidity in primary care (PC), interdisciplinary PC teams supported by appropriate clinical information systems (CIS) are needed in order to deal with the complexity of multimorbid patients' care. Our team has developed such a system, called the Da Vinci system. However, despite the expected benefits,(More)
Statins reduce cardiovascular morbidity and mortality after continuous treatment. Studies have shown that less than 50% of patients take 80% or more of prescribed doses 1 year after starting therapy. To evaluate the impact of statin adherence on the incidence of coronary artery disease (CAD). A cohort of 115,290 patients was reconstructed using the Régie de(More)
BACKGROUND Antihypertensive agents have been found to decrease morbidity and/or mortality associated with cardiovascular disease (CVD). Surveys have shown that hypertension has been diagnosed in many patients but remains uncontrolled. One factor may be the lack of persistence to treatment. OBJECTIVE To evaluate persistence with antihypertensives and its(More)
AIMS Statins are effective in the prevention of an atherosclerotic event, e.g. coronary artery disease and cerebrovascular disease. Patients at high risk of cardiovascular disease (CVD), such as chronic heart failure (CHF), might benefit from the effects of statin therapy. However, one question that has not yet been answered and that may clarify the role of(More)