Lyndon Fawcett

Learn More
Cryoglobulins obtained from malaria-infected (Plasmodium berghei berghei) Balb/c mice were administered intraperitoneally to naive Balb/c mice. Ten days or 9 months following cryoglobulin administration, the naive mice were infected with malaria. Comparison of sera from cryoglobulin-treated malaria-infected mice with sera from control infected mice revealed(More)
In 1961 we reported that heterologous kidney antiserum when injected into pregnant rats resulted in wide spectrum of congenital malformations. Further studies identified that it was the IgG component of the antiserum that was teratogenic and that complement was not necessary to produce the teratogenic effect. Labeled antibody studies demonstrated that the(More)
Hemocytes of the hard clam Mercenaria mercenaria migrate toward secreted bacterial products in vitro by chemotaxis (i.e., by detection of an increasing chemical gradient of attractant). The attractants produced by Escherichia coli are peptides or small proteins. Clam hemocytes also migrate toward formyl-methionyl-leucyl-phenylalanine (fMLF), a mammalian(More)
Network service composition is becoming increasingly flexible, thanks in part to advances in virtualisation and cloud technologies. As these penetrate further into networks, providers are often looking to leverage this infrastructure to improve their service delivery. This desire poses a number of obstacles, including a diversity in device capabilities and(More)
Several animal models of arthritis are produced using complete Freund's adjuvant (CFA) alone or with collagen as an arthritogen. Successful induction of arthritis is reported to require that the adjuvant mixture be administered by intradermal or subcutaneous routes. The resulting arthritis is caused by primarily cellular immune responses. Data presented in(More)
The continuing growth in the mobile phone arena, particularly in terms of device capabilities and ownership, is having a transformational impact on media consumption. It is now possible to consider orchestrated multistream experiences delivered across many devices, rather than the playback of content from a single device. However, there are significant(More)
Teratology and genetic counselors are frequently asked whether very low exposures of drugs and chemicals can cause a child's congenital malformations. One critical factor on which the counseling is based is the dose. Because teratogenic effects follow a toxicologic dose-response curve with a no-effect dose, frequently counselors can refute a causal(More)
We previously described a high incidence of digit/limb anomalies in the offspring of A/J mice subjected to surgery on day 12.5 postconception (p.c.), but not in the offspring of untreated control mice. To investigate the cause of these defects, we compared the offspring of mice in experimental groups involving adrenalectomy, sham adrenalectomy, blood(More)
The serum levels of total and visceral yolk sac (VYS)-reactive sheep IgG have been determined following injection of a teratogenic sheep anti-VYS antiserum. After intravenous injection, levels of VYS-reactive IgG fell rapidly, with 75% of the amount in the injection removed in the first 5 min, and 90% by 60 min. By contrast, 90% or more of the total sheep(More)