Lynda V. Wilton

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BACKGROUND A substantial number of women of childbearing age suffer from schizophrenia and other mental illnesses that require the use of antipsychotic drugs. Atypical antipsychotics have been on the market since the mid-1990s, and to date there are no prospective comparative studies regarding use during pregnancy. OBJECTIVES (1) To determine whether(More)
BACKGROUND Mirtazapine is a novel piperazinoazepine antidepressant, unrelated to any known class of antidepressants. Currently, apart from a few case reports and case series in the literature, there are no studies evaluating the safety of this drug during pregnancy. OBJECTIVE To determine whether mirtazapine increases the risk for major malformations in(More)
BACKGROUND Varenicline tartrate (Champix), a new smoking cessation medicine, was launched in the UK in December 2006. Varenicline is a highly selective partial agonist of the alpha(4)beta(2) nicotinic acetylcholine receptor (alpha(4)beta(2) receptor). The partial agonistic binding leads to alleviation of symptoms of craving and withdrawal, and(More)
BACKGROUND AND OBJECTIVES Rofecoxib, a selective cyclo-oxygenase (COX)-2 inhibitor, was a widely marketed drug that was used for relief of pain and inflammation in arthritic conditions. It was withdrawn from the market worldwide in September 2004 because of an increased risk of cardiovascular events. Celecoxib, which belongs to the same class of drugs, is(More)
PURPOSE To examine the safety of lamotrigine (LTG) used in general practice to treat epilepsy. METHODS Information was collected on 11,316 patients who were included in a noninterventional observational cohort study conducted by means of Prescription-Event Monitoring (PEM). A follow-up study provided information on the first 3,994 patients who had taken(More)
BACKGROUND Using postmarketing pharmacovigilance data collected shortly after market authorization of lamotrigine in the UK, a study was conducted to compare the adverse event (AE) profiles of children and adults taking lamotrigine, using modified signal detection methods. METHODS Data from the lamotrigine Prescription Event Monitoring (PEM) study, an(More)
OBJECTIVE To examine the safety of sildenafil, the first of the phosphodiesterase type 5 inhibitors licensed for the treatment of male erectile dysfunction (ED), as used in general medical practice in England, quantifying the incidence of a range of events in patients treated with sildenafil, and identifying any previously unrecognized adverse drug(More)
OBJECTIVE To determine the proportion and nature of congenital anomalies in babies born to women exposed to newly marketed drugs during the first trimester. DESIGN Non-interventional observational cohort studies. METHODS The women were identified in confidence by the Prescription Pricing Authority. The doctor was sent a questionnaire to determine(More)
Psychiatry Psychiatr Epidemiol 1991;26:104-14. 10 Blazer DG, Kessler RC, McGonagle KA, Swartz MS. The prevalence and distribution of major depression in a national community sample: the national comorbidity survey. Am J Psychiatry 1994;151:979-86. 11 Weich S, Lewis G. Material standard of living, social class and the prevalence of the common mental(More)
1 Wilkinson RG. Income distribution and life expectancy. BMJ 1992;304:165-8. 2 Wilkinson RG. Unhealthy societies: the afflictions of inequality. London: Routledge, 1996. 3 Kaplan GA, Pamuk E, Lynch JW, Cohen RD, Balfour JL. Inequality in income and mortality in the United States: analysis of mortality and potential pathways. BMJ 1996;312:999-1003. 4 Kennedy(More)