Lyn S. Chitty

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The matching criteria were gestation (using an ultrasound crown–rump length or biparietal diameter measurement), duration of storage, and centre. Screening performance of the individual markers and combinations of markers together with maternal age was assessed using standard methods. In addition pairs of first and second trimester serum samples from 600(More)
BACKGROUND Post-mortem MRI is a potential diagnostic alternative to conventional autopsy, but few large prospective studies have compared its accuracy with that of conventional autopsy. We assessed the accuracy of whole-body, post-mortem MRI for detection of major pathological lesions associated with death in a prospective cohort of fetuses and children. (More)
We describe new charts and tables for dating pregnancies derived from data collected in a study designed to enable the construction of these and charts of fetal size. This was a prospective study in which 663 fetuses seen in the routine ultrasound clinic in a London teaching hospital were scanned once only for the purpose of this study. We discuss the(More)
BACKGROUND The introduction of non-invasive prenatal testing (NIPT) for Down's syndrome into routine state-funded antenatal care in the UK is approaching. METHODS We conducted qualitative one-to-one interviews with 40 pregnant women to ascertain their views on using NIPT for Down's syndrome. RESULTS The overwhelming majority of women viewed NIPT as a(More)
Chondrodysplasia punctata (CDP) is associated with a number of disorders, including inborn errors of metabolism, involving peroxisomal and cholesterol pathways, embryopathy and chromosomal abnormalities. Several classification systems of the different types of CDP have been suggested earlier. More recently, the biochemical and molecular basis of a number of(More)
OBJECTIVE To assess the implications of a change in prenatal diagnosis policy from full karyotype analysis to rapid trisomy testing for women referred primarily for increased risk of Down's Syndrome. DESIGN Retrospective collection and review of data. SETTING The four London Regional Genetics Centres. POPULATION Pregnant women (32,674) in the London(More)
OBJECTIVE To evaluate prenatal diagnosis in facilitating prenatal counselling and planning optimal perinatal care for persistent cloaca, a complex malformation with variable presentation and a difficult reconstructive challenge for the paediatric urologist and surgeon. PATIENTS AND METHODS The prenatal records of six patients with a suspected prenatal(More)
OBJECTIVE To assess amniotic fluid for evidence of an inflammatory exudate in association with fetal gastroschisis. SETTING University College Hospital, London and Institute of Child Health, London. SAMPLE Samples of amniotic fluid in the third trimester from pregnant women with a diagnosis of fetal gastroschisis (n = 10) and from a control group (n =(More)
OBJECTIVE To investigate an approach for the analysis of samples obtained in screening for trisomy 21 that retains the advantages of quantitative fluorescent polymerase chain reaction (qf-PCR) over full karyotyping and maximises the detection of clinically significant abnormalities. DESIGN Observational study. SETTING Tertiary referral centre. (More)
OBJECTIVE To assess the views and likely uptake of non-invasive prenatal testing (NIPT) for trisomy 21 among potential service users in the UK. DESIGN Cross-sectional survey. SETTING Four antenatal clinics in England and two websites. SAMPLE A total of 1131 women and partners. METHODS Questionnaire conducted with women (and partners) recruited(More)