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This paper describes a senior/graduate level course in hardware logic verification being offered by The Ohio State University in cooperation with IBM. The need for the course is established through the growing importance of logic verification to users of custom logic designs. We discuss the short-term and long-term goals for the course, and describe the(More)
The association between autoimmune hemolytic anemia (AIHA) and subsequent appearance of lymphoproliferative disorders (LPDs) has not been properly addressed in large-scale studies. We evaluated 107 patients with idiopathic (67 patients) or underlying (40 patients) immune disorders diagnosed with AIHA between 1992 and 1999. The following variables were(More)
Disseminated intravascular coagulation (DIC) is a well known hemostatic complication of solid tumors. We evaluated the occurrence of DIC in 1117 patients with solid tumors. Of these patients, 76 (6.8%) were diagnosed with DIC. There were a total of 145 bleeding and clotting episodes reported in the 76 patients. Thrombocytopenia, hypofibrinogemia, elevated(More)
A method was developed to purify human blood basophils using monoclonal mouse IgE. Enriched suspensions of basophils were sensitized with IgE anti-trinitrophenol (TNP) hapten which was prepared from hybridoma culture supernatants. Rosettes were induced with TNP-coupled red cells and separated from contaminating cells on Percoll gradients. Basophils were(More)
Between 1995 and 1998, we treated 5 patients with anti-factor VIII antibodies and spontaneous bleeding. All patients had underlying malignant conditions. Initial control of the bleeding episodes and reduction in inhibitor titer was achieved in all patients. Disappearance of factor VIII inhibitor occurred in 3 patients after either resection of the tumor or(More)
In this third paper on the kinetics of lymphocyte stimulation we present a simple stochastic model for the entry of mitogen stimulated human lymphocytes into the proliferative cycle. The model is based on the assumption that responder 'recruitment' is a process of simple exponential decay. The model can be applied to the initial rapid rise in thymidine(More)
OBJECTIVES To evaluate the occurrence of acquired hemophilia in patients with hematologic malignancies and to assess their response to treatment. DESIGN Data on 8 patients with hematologic neoplastic disorders and inhibitor against factor VIII were analyzed retrospectively. SETTING Three large tertiary-care centers. RESULTS All 8 patients presented(More)
OBJECTIVE To evaluate the occurrence of megaloblastic anemia induced by the infusion of therapeutic or prophylactic methotrexate in patients with acute leukemia. DESIGN Data on 3 patients with acute leukemia receiving intrathecal methotrexate were prospectively analyzed. SETTING Large tertiary-care center. RESULTS All 3 patients with acute leukemia(More)
The present investigation was designed to test the admittedly speculative hypothesis that a factor involved in the etiology of human lymphatic and hematopoietic neoplasms may be transmitted by blood transfusion prior to the clinical onset of illness in the donor. One hundred and five New York State residents, who received blood from donors who subsequently(More)
The kinetics of thymidine uptake in human peripheral lymphocytes stimulated by allogenic cells, antigen E (ragweed allergen) and a variety of mitogens can generally be divided into four consecutive phases. First, a lag period with no increase in thymidine uptake, then a short period of rapid change in uptake, followed by a log-linear growth period and(More)