Lyle E. Muller

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The number of connected components and the size of the largest connected component are studied under node and edge removal in the connectivity graph of the C. elegans nervous system. By studying the two subgraphs – the directed graph of chemical synapses and the undirected graph of electrical junctions – we observe that adding a small number of undirected(More)
In the past two decades, significant advances have been made in understanding the structural and functional properties of biological networks using graph-theoretic analysis. In general, most graph-theoretic studies are conducted in the presence of serious uncertainties, such as major undersampling of the experimental data. In the specific case of neural(More)
Beta (β)- and gamma (γ)-oscillations are present in different cortical areas and are thought to be inhibition-driven, but it is not known if these properties also apply to γ-oscillations in humans. Here, we analyze such oscillations in high-density microelectrode array recordings in human and monkey during the wake-sleep cycle. In these recordings, units(More)
The correlation method from brain imaging has been used to estimate functional connectivity in the human brain. However, brain regions might show very high correlation even when the two regions are not directly connected due to the strong interaction of the two regions with common input from a third region. One previously proposed solution to this problem(More)
Copyright Muller et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited. Abstract During sleep, the thalamus generates a characteristic pattern of transient, 11-15 Hz sleep spindle oscillations, which(More)
During sleep, the thalamus generates a characteristic pattern of transient, 11-15 Hz sleep spindle oscillations, which synchronize the cortex through large-scale thalamocortical loops. Spindles have been increasingly demonstrated to be critical for sleep-dependent consolidation of memory, but the specific neural mechanism for this process remains unclear.(More)
The existence of propagating waves, either spontaneous or stimulus-evoked, in neocortex during the awake state has been a subject of recent interest [1,2]. Here, following work done previously in voltage-sensitive dye imaging of the primary visual cortex in the awake monkey [3], we apply an analysis method for non-parametric, automated detection of(More)