Lyle E. Muller

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Propagating waves of activity have been recorded in many species, in various brain states, brain areas, and under various stimulation conditions. Here, we review the experimental literature on propagating activity in thalamus and neocortex across various levels of anesthesia and stimulation conditions. We also review computational models of propagating(More)
Propagating waves occur in many excitable media and were recently found in neural systems from retina to neocortex. While propagating waves are clearly present under anaesthesia, whether they also appear during awake and conscious states remains unclear. One possibility is that these waves are systematically missed in trial-averaged data, due to(More)
The number of connected components and the size of the largest connected component are studied under node and edge removal in the connectivity graph of the C. elegans nervous system. By studying the two subgraphs – the directed graph of chemical synapses and the undirected graph of electrical junctions – we observe that adding a small number of undirected(More)
Propagating waves of activity are seen in many types of excitable media, and in recent years, were found in the neocortex of anesthetized animals [1,2]. To date, however , it still remains unclear whether propagating waves appear during awake and conscious states [3,4]. One possibility is that these waves are systematically missed in trial-averaged data,(More)
In the past two decades, significant advances have been made in understanding the structural and functional properties of biological networks using graph-theoretic analysis. In general, most graph-theoretic studies are conducted in the presence of serious uncertainties, such as major undersampling of the experimental data. In the specific case of neural(More)
Beta (β)- and gamma (γ)-oscillations are present in different cortical areas and are thought to be inhibition-driven, but it is not known if these properties also apply to γ-oscillations in humans. Here, we analyze such oscillations in high-density microelectrode array recordings in human and monkey during the wake-sleep cycle. In these recordings, units(More)
The existence of propagating waves, either spontaneous or stimulus-evoked, in neocortex during the awake state has been a subject of recent interest [1,2]. Here, following work done previously in voltage-sensitive dye imaging of the primary visual cortex in the awake monkey [3], we apply an analysis method for non-parametric, automated detection of(More)