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Chemokines have been shown to be effective bactericidal molecules against a variety of bacteria and fungi in vitro. These direct antimicrobial effects are independent of their chemotactic activities involving immunological receptors. However, the direct biological role that these proteins may play in host defense, particularly against intestinal pathogens,(More)
The aims of this study were to assess the prevalence of isolates of Beijing lineage in childhood tuberculosis (TB) and the association between strain family and clinical characteristics. A total of 105 children aged less than 18 years with culture-confirmed TB were evaluated by spoligotyping and the 12-locus mycobacterial interspersed repetitive(More)
Crohn's disease (CD) is a chronic inflammatory condition of diverse etiology. Exposure to foodborne pathogens causing acute gastroenteritis produces a long-term risk of CD well into the post-infectious period but the mechanistic basis for this ongoing relationship to disease onset is unknown. We developed two novel models to study the comorbidity of acute(More)
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