Lydia Sorokin

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Myelinating glial cells exhibit a spectacular cytoarchitecture, because they polarize on multiple axes and domains. How this occurs is essentially unknown. The dystroglycan-dystrophin complex is required for the function of myelin-forming Schwann cells. Similar to other tissues, the dystroglycan complex in Schwann cells localizes with different dystrophin(More)
Laminins are a family of disulfide-linked heterotrimeric proteins consisting of 3 different subunits termed alpha, beta, and gamma chains. Combinations of 11 characterized laminin subunits (alpha 1-alpha 5, beta 1-beta 3, and gamma 1-gamma 3) generate at least 12 laminin isoforms, which can serve different functions. Although expression of laminin in the(More)
Laminin-8 (alpha 4 beta 1 gamma 1) is one of the major laminin isoforms expressed in vascular endothelial basement membranes. Here we show that deletion of laminin-8 in mice affects angiogenesis under pathological conditions. Murine tumor models used in laminin alpha 4-deficient mice results in hyperneovascularization and significant promotion of tumor(More)
Laminins, the main components of basement membranes, are heterotrimers consisting of ␣ , ␤ , and ␥ polypeptide chains linked together by disulfide bonds. Laminins-1 and-2 are both composed of ␤ 1 and ␥ 1 chains and differ from each other on their ␣ chain, which is ␣ 1 and ␣ 2 for laminin-1 and-2, respectively. The present study shows that whereas laminins-1(More)
Laminins (LM), basement membrane molecules and mediators of epithelial-stromal communication, are crucial in tissue homeostasis. Inflammatory Bowel Diseases (IBD) are multifactorial pathologies where the microenvironment and in particular LM play an important yet poorly understood role in tissue maintenance, and in cancer progression which represents an(More)
is extensive information on the role of cell adhesion molecules, inflammatory cytokines and chemo kines in promoting leukocyte infiltration and functions in inflamed tissues 1–3. The advent of in situ immunology and intravital microscopy for the study of immune responses has shown that the extracellular matrix (ECM) has an important role in influencing(More)
Laminin-8 (␣4␤1␥1) is one of the major laminin isoforms expressed in vascular endothelial basement membranes. Here we show that deletion of laminin-8 in mice affects angiogenesis under pathological conditions. Mu-rine tumor models used in laminin ␣4-deficient mice results in hyperneo-vascularization and significant promotion of tumor growth and metasta-sis.(More)
It has been previously shown that A-chain and domain(E8)-specific antibodies to laminin that inhibit cell adhesion also interfere with the establishment of epithelial cell polarity during kidney tubule development A monoclonal antibody specific for the integrin c~6 subunit, which selectively blocks cell binding to E8, was used to study the receptors(More)
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