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Acetylcholine (ACh) is the primary parasympathetic neurotransmitter in the airways. Recently, it was established that ACh, via muscarinic receptors, regulates airway remodeling in animal models of… (More)
Transforming growth factor-β₁ (TGF-β₁) is a central mediator in tissue remodeling processes, including fibrosis and airway smooth muscle (ASM) hyperplasia, as observed in asthma. The mechanisms… (More)
The fibrogenic cytokine transforming growth factor-β1 (TGFβ1) is an important mediator in airway remodelling. TGFβ1 overexpression in mice induces airway smooth muscle (ASM) hyperplasia, one of the… (More)