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RNF8 promotes epithelial-mesenchymal transition of breast cancer cells
- Jingyu Kuang, L. Li, +8 authors G. Shao
- Journal of experimental & clinical cancer…
- 4 June 2016
RNF8 induces EMT in the breast cancer cells and promotes breast cancer metastasis, suggesting that RNF8 could be used as a potential therapeutic target for the prevention and treatment of breast cancer. Expand
Caged circular siRNAs for photomodulation of gene expression in cells and mice† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c7sc03842a
Caged siRNAs with a circular structure were successfully used for photoregulation of target genes in both cells and mice.
Dextran-Conjugated Caged siRNA Nanoparticles for Photochemical Regulation of RNAi-Induced Gene Silencing in Cells and Mice.
- Changmai Chen, Zhong-yu Wang, Jinhao Zhang, Xinli Fan, Luzheng Xu, Xinjing Tang
- Medicine, Chemistry
- Bioconjugate chemistry
- 16 April 2019
Caged siRNA nanoparticles with high serum stability not only show great promise for photoregulation of exogenous and endogenous gene expression for both in vitro and in vivo applications, but also provide a novel and convenient way to spatiotemporally control RNAi-induced gene silencing. Expand
Trace elements differences in the depression sensitive and resilient rat models.
- Luzheng Xu, S. Zhang, +7 authors Bing Cao
- Medicine, Chemistry
- Biochemical and biophysical research…
- 20 August 2020
The higher levels of iron, calcium, selenium, manganese and cobalt in the resilient group indicated these trace elements might be protective against the development of depressive symptoms in response to stress. Expand
Additional file 1: of RNF8 promotes epithelial-mesenchymal transition of breast cancer cells
RNF8 Promotes Lung Cancer Tumorigenesis and Chemoresistance by Regulating AKT
This study identified RNF8 as the E3 ligase for regulating the activation of Akt via K63-linked ubiquitination under both physiological and genotoxic conditions, which leads to tumorigenesis and chemoresistance in lung cancer. Expand