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Pre-Clinical Evaluation of a Novel Nanoemulsion-Based Hepatitis B Mucosal Vaccine

• Paul E. Makidon, Anna U. Bielinska, +11 authors James R Baker
• PloS one
• 2008

BACKGROUND Hepatitis B virus infection remains an important global health concern despite the availability of safe and effective prophylactic vaccines. Limitations to these vaccines include… (More)

Iron induces bimodal population development by Escherichia coli.

• William H Depas, David A. Hufnagel, +6 authors Matthew R Chapman
• Proceedings of the National Academy of Sciences…
• 2013

Bacterial biofilm formation is a complex developmental process involving cellular differentiation and the formation of intricate 3D structures. Here we demonstrate that exposure to ferric chloride… (More)

Diversity, biogenesis and function of microbial amyloids.

• Luz P. Blanco, Margery L. Evans, Daniel R. Smith, Matthew P Badtke, Matthew R Chapman
• Trends in microbiology
• 2012

Amyloid is a distinct β-sheet-rich fold that many proteins can acquire. Frequently associated with neurodegenerative diseases in humans, including Alzheimer's, Parkinson's and Huntington's diseases,… (More)

Induction of Th17 cellular immunity with a novel nanoemulsion adjuvant.

• Anna U. Bielinska, Michele Stenehjem Gerber, +5 authors James R Baker
• Critical reviews in immunology
• 2010

T17 (T-helper-17) cytokine responses have been recently recognized as an important component for the protective immunity produced by vaccination. However, the mechanism by which immune adjuvants… (More)

Bacterial amyloids.

• Yizhou Zhou, Luz P. Blanco, Daniel R. Smith, Matthew R Chapman
• Methods in molecular biology
• 2012

Many bacteria can assemble functional amyloid fibers on their cell surface. The majority of bacterial amyloids contribute to biofilm or other community behaviors where cells interact with a surface… (More)

Nanoemulsion mucosal adjuvant uniquely activates cytokine production by nasal ciliated epithelium and induces dendritic cell trafficking.

• Paul E. Makidon, Igor M. Belyakov, +5 authors James R Baker
• European journal of immunology
• 2012

While the nasal mucosa is a potentially useful site for human immunization, toxin-based nasal adjuvants are generally unsafe and less effective in humans. Safe mucosal adjuvants that activate… (More)

Induction of immune response to the 17 kDa OMPA Burkholderia cenocepacia polypeptide and protection against pulmonary infection in mice after nasal vaccination with an OMP nanoemulsion-based vaccine

• Paul E. Makidon, Jessica Knowlton, +4 authors James R Baker
• Medical Microbiology and Immunology
• 2009

Burkholderia cepacia complex (Bcc) are opportunistic bacteria associated with life-threatening illness in persons with cystic fibrosis. Once Bcc colonization is established, these… (More)

Bacterial-associated cholera toxin and GM1 binding are required for transcytosis of classical biotype Vibrio cholerae through an in vitro M cell model system.

• Luz P. Blanco, Victor J DiRita
• Cellular microbiology
• 2006

To elucidate mechanisms involved in M cell uptake and transcytosis of Vibrio cholerae, we used an in vitro model of human M-like cells in a Caco-2 monolayer. Interspersed among the epithelial… (More)

Distinct pathways of humoral and cellular immunity induced with the mucosal administration of a nanoemulsion adjuvant.

• Anna U. Bielinska, Paul E. Makidon, +7 authors James R Baker
• Journal of immunology
• 2014

Nasal administration of an oil-in-water nanoemulsion (NE) adjuvant W805EC produces potent systemic and mucosal, Th-1- and Th-17-balanced cellular responses. However, its molecular mechanism of action… (More)

The Production of Curli Amyloid Fibers Is Deeply Integrated into the Biology of Escherichia coli

• Daniel R. Smith, Janet E. Price, Peter E. Burby, Luz P. Blanco, Justin Chamberlain, Matthew R Chapman
• Biomolecules
• 2017

Curli amyloid fibers are the major protein component of the extracellular matrix produced by Enterobacteriaceae during biofilm formation. Curli are required for proper biofilm development and… (More)

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