Learn More
BACKGROUND Activity-dependent competition that operates on branch stability or formation plays a critical role in shaping the pattern and complexity of axonal terminal arbors. In the mammalian central nervous system (CNS), the effect of activity-dependent competition on axon arborization and on the assembly of sensory maps is well established. However, the(More)
Individuals with 22q11.2 microdeletions have cognitive deficits and a high risk of developing schizophrenia. Here we provide evidence that primary hippocampal neurons from a mouse model of 22q11.2 deletion (Df(16)A+/− mice) have decreased density of dendritic spines and glutamatergic synapses, as well as impaired dendritic growth. These deficits were(More)
Jun Mukai1, Alefiya Dhilla2, Liam J. Drew1, Kimberly L. Stark3, Luxiang Cao1, Amy B. MacDermott1,4, Maria Karayiorgou3,^, and Joseph A. Gogos1,4,^ 1Columbia University, College of Physicians & Surgeons, Department of Physiology and Cellular Biophysics, 630 West 168th Street, New York, NY 10032 2Columbia University, College of Physicians & Surgeons,(More)
  • 1