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One form of crowdsourcing is the competition, which poses an open call for competing solutions. Commercial systems such as TopCoder have begun to explore the application of competitions to software development, but have important limitations diminishing the potential benefits drawn from the crowd. In particular, they employ a model of independent work that(More)
To evaluate the role of mtDNA in breast cancer. We carried out an investigation into the mtDNA major control region or D-loop region and an essential and the largest mtDNA protein-coding gene, NADH dehydrogenase subunit 5 (ND5), together with a mitochondrial haplogroup analysis in 64 patients with breast cancer (BC) and 54 patients with benign breast(More)
Dysregulation of mammalian target of rapamycin (mTOR) in hepatocellular carcinoma (HCC) represents a valuable treatment target. Recent studies have developed a highly-selective and potent mTOR kinase inhibitor, CZ415. Here, we showed that nM concentrations of CZ415 efficiently inhibited survival and induced apoptosis in HCC cell lines (HepG2 and Huh-7) and(More)
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