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MRI-based medical image analysis for brain tumor studies is gaining attention in recent times due to an increased need for efficient and objective evaluation of large amounts of data. While the pioneering approaches applying automated methods for the analysis of brain tumor images date back almost two decades, the current methods are becoming more mature(More)
X-ray imaging is one of the most commonly used medical imaging modality. Albeit X-ray radiographs provide important clinical information for diagnosis, planning and post-operative follow-up, the challenging interpretation due to its 2D projection characteristics and the unknown magnification factor constrain the full benefit of X-ray imaging. In order to(More)
Ligament balancing in total knee arthroplasty may have an important influence on joint stability and prosthesis lifetime. In order to provide quantitative information and assistance during ligament balancing, a device that intraoperatively measures knee joint forces and moments was developed. Its performance and surgical advantages were evaluated on six(More)
STUDY DESIGN This is an experimental study on an artificial vertebra model and human cadaveric spine. OBJECTIVE Characterization of polymethylmethacrylate (PMMA) bone cement distribution in the vertebral body as a function of cement viscosity, bone porosity, and injection speed. Identification of relevant parameters for improved cement flow predictability(More)
STUDY DESIGN In vitro biomechanical testing of thoracic spine specimens using a standardized three-dimensional spine flexibility protocol. OBJECTIVES To compare the mechanical stability of the intrapedicular and extrapedicular technique for pedicle screw placement. The hypothesis was that extrapedicular screw placement provides an equally rigid construct.(More)
Seventeen bones (sixteen cadaveric bones and one plastic bone) were used to validate a method for reconstructing a surface model of the proximal femur from 2D X-ray radiographs and a statistical shape model that was constructed from thirty training surface models. Unlike previously introduced validation studies, where surface-based distance errors were used(More)
STUDY DESIGN Ex vivo in vitro study evaluating a novel intervertebral disc/endplate culture system. OBJECTIVES To establish a whole-organ intervertebral disc culture model for the study of disc degeneration in vitro, including the characterization of basic cell and organ function. SUMMARY OF BACKGROUND DATA With current in vivo models for the study of(More)
A new concept for the anchorage of anterior fixation implants in the osteoporotic thoracic and lumbar spine is presented. The SpiralBlade has been proposed as a suitable device for use in the osteoporotic spine, due to its broad, flat surface, which should provide resistance against cut-out of the implant through the vertebral body under dynamic loading.(More)