Lutz Hilterhaus

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We have been combining computational methods with experimental tests to gently modify glucose-6-phosphate dehydrogenase (G6PDH) from Leuconostoc mesenteroides for two specific goals. Firstly, it should be immobilized on an inorganic substrate as part of a longer-term project involving microreactor methods. Secondly, the natural enzyme is found as a(More)
Levulinic acid is a feasible platform chemical derived from acid-catalyzed hydrolysis of lignocellulose. The conversion of this substrate to (S)-γ-valerolactone ((S)-GVL) was investigated in a chemo-enzymatic reaction sequence that benefits from mild reaction conditions and excellent enantiomeric excess of the desired (S)-GVL. For that purpose, levulinic(More)
The enzyme arylmalonate decarboxylase (AMDase) enables the selective synthesis of enantiopure (S)-arylpropinates in a simple single-step decarboxylation of dicarboxylic acid precursors. However, the poor enzyme stability with a half-life time of about 1.2 h under process conditions is a serious limitation of the productivity, which results in a need for(More)
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