Learn More
OBJECTIVE To develop a technique for recognizing critical situations based on laboratory results in settings in which a normal range cannot be defined, because what is "normal" differs widely from patient to patient. To assess the potential of this approach for kidney transplant recipients, where recognition of acute rejections is based on the pattern of(More)
BACKGROUND Health care professionals worldwide attend courses and workshops to learn evidence-based medicine (EBM), but evidence regarding the impact of these educational interventions is conflicting and of low methodologic quality and lacks generalizability. Furthermore, little is known about determinants of success. We sought to measure the effect of EBM(More)
BACKGROUND Cyclosporin A (CyA) is a drug with a narrow therapeutic window and highly variable pharmacokinetics. Therapeutic drug monitoring is essential and conventionally has been guided by trough levels (C0). Recent evidence indicates that a single blood concentration measurement 2 h after CyA administration (C2) is a more accurate predictor of drug(More)
A b s t r a c t Objective: To develop a technique for recognizing critical situations based on laboratory results in settings in which a normal range cannot be defined, because what is " normal " differs widely from patient to patient. To assess the potential of this approach for kidney transplant recipients , where recognition of acute rejections is based(More)
  • 1