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Selective Modulation of Axonal Sodium Channel Subtypes by 5‐HT1A Receptor in Cortical Pyramidal Neuron
TLDR
Results reveal a selective modulation of NaV1.2 distributed at the proximal AIS region and AP backpropagation by 5‐HT1A receptors, suggesting a potential mechanism for serotonergic regulation of functional polarization in the dendro‐axonal axis, synaptic plasticity and PFC functions. Expand
Developmental reduction of asynchronous GABA release from neocortical fast-spiking neurons.
TLDR
Recording from fast-spiking interneurons and pyramidal cells in prefrontal cortical slices obtained from juvenile and adult rats revealed that the AR strength was stronger at juvenile but weaker in adult, possibly resulting from changes in presynaptic Ca(2+) dynamics. Expand
A Common Neuroendocrine Substrate for Diverse General Anesthetics and Sleep
TLDR
A core ensemble of hypothalamic neurons in and near the supraoptic nucleus, consisting primarily of neuroendocrine cells, which are persistently and commonly activated by multiple classes of GA drugs are discovered, which identify a common neural substrate underlying diverse GA drugs and natural sleep and reveal a crucial role of the neuro endocrine system in regulating global brain states. Expand
Differential roles of NaV1.2 and NaV1.6 in regulating neuronal excitability at febrile temperature and distinct contributions to febrile seizures
TLDR
It is demonstrated that somatic and axonal sodium channels primarily mediated through NaV1.2 and NaV 1.6 subtypes, respectively, behave differentially at FT, and might play distinct roles in FS generation, and predicts potential outcomes of alterations in sodium channel subtype composition. Expand
Autapses enhance bursting and coincidence detection in neocortical pyramidal cells
TLDR
It is shown that in the mammalian neocortex, autapses of pyramidal cells can enhance burst firing and coincidence detection from other inputs, indicating that PC autapses are functional and represent an important circuit element in the neocortex. Expand
General Anesthetics Activate a Potent Central Pain-Suppression Circuit in the Amygdala
TLDR
It is shown that general anesthesia activates a distinct population of central amygdala neurons and that these neurons can potently suppress pain responses through their widespread projections to many pain-processing centers in the brain. Expand
Firing Frequency Maxima of Fast-Spiking Neurons in Human, Monkey, and Mouse Neocortex
TLDR
It is revealed that FS neurons in human association cortices could generate APs at a maximal mean frequency of 338 Hz and a maximal instantaneous frequency of 453 Hz, and they increase with age, while the maximal firing frequency of FS neurons varies between species and cortical areas. Expand
A Subtype of Inhibitory Interneuron with Intrinsic Persistent Activity in Human and Monkey Neocortex.
TLDR
A distinct subpopulation of neurons with intrinsic persistent activity that could be triggered by single action potentials but terminated by bursts of APs was found, suggesting that this type of neuron could be unique to primates. Expand
A Phenomenological Synapse Model for Asynchronous Neurotransmitter Release
TLDR
A phenomenological model for asynchronous neurotransmitter release is developed, which captures the fundamental features of the asynchronous release process, and is simple enough to be incorporated in large-size network simulations. Expand