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The neural correlates of intraindividual response variability were investigated in a serial choice reaction time (CRT) task. Reaction times (RTs) from the faster and slower portions of the RT distribution for the task were separately aggregated and associated P300 event-related potentials computed. Independent behavioral measures of executive function and(More)
Autism spectrum disorder (ASD) is one of the most common neurodevelopmental dis­ orders, but effective medical treatments for the core symptoms of the disorder are still lack­ ing. According to the Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM­5), the core symptoms of ASD comprise deficits in social communication and inter­(More)
We investigated the electrophysiological correlates of somatosensory processing under different arm postures by recording event-related potentials at frontal, central and centroparietal sites during tactile stimulation of the hands. Short series of 200 ms vibrotactile stimuli were presented to the palms of the participants' hands, one hand at a time, in(More)
Previous theoretical and experimental works has shown that preparing to act causes enhanced perceptual processing at movement-relevant locations. Up until now, this has focused almost exclusively on the goal of an action, neglecting the role of the effector. We addressed this by measuring changes in visual processing across time during motor preparation at(More)
Author details Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King’s College London, London, UK. Centre for Brain and Cognitive Development, Birkbeck, University of London, London, UK. MRC Social, Genetic and Developmental Psychiatry Centre, IoPPN, King’s College London, London, UK. NIHR(More)
An ability to perceive tactile and visual stimuli in a common spatial frame of reference is a crucial ingredient in forming a representation of one's own body and the interface between bodily and external space. In this study, the authors investigated young infants' abilities to perceive colocation between tactile and visual stimuli presented on the hands.(More)
BACKGROUND The EU-AIMS Longitudinal European Autism Project (LEAP) is to date the largest multi-centre, multi-disciplinary observational study on biomarkers for autism spectrum disorder (ASD). The current paper describes the clinical characteristics of the LEAP cohort and examines age, sex and IQ differences in ASD core symptoms and common co-occurring(More)
An ability to perceive tactile and visual stimuli in a common spatial frame of reference is a crucial ingredient in forming a representation of one’s own body and the interface between bodily and external space. In this study we investigated young infants’ abilities to perceive co-location between tactile and visual stimuli presented on the hands. We(More)
Within the Developmental Coordination Disorder (DCD) literature the primary research focus has been directed towards children with DCD. Little has been investigated regarding the long term prognosis of these individuals with regards to the impact of the disorder in later life. Also, previous investigations and resulting suggestions of underlying aetiology(More)
BACKGROUND The tremendous clinical and aetiological diversity among individuals with autism spectrum disorder (ASD) has been a major obstacle to the development of new treatments, as many may only be effective in particular subgroups. Precision medicine approaches aim to overcome this challenge by combining pathophysiologically based treatments with(More)
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