Luke Martinson

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The early detection of relapse following primary surgery for non-small-cell lung cancer and the characterization of emerging subclones, which seed metastatic sites, might offer new therapeutic approaches for limiting tumour recurrence. The ability to track the evolutionary dynamics of early-stage lung cancer non-invasively in circulating tumour DNA (ctDNA)(More)
CD25 is expressed at high levels on regulatory T (Treg) cells and was initially proposed as a target for cancer immunotherapy. However, anti-CD25 antibodies have displayed limited activity against established tumors. We demonstrated that CD25 expression is largely restricted to tumor-infiltrating Treg cells in mice and humans. While existing anti-CD25(More)
Elevation or depression of the ST segment of the 12-lead electrocardiogram is an important and established marker of myocardial ischemia or injury. The ST segment deviation in normal individuals using standard cardiac monitoring equipment in the clinical setting of prehospital transport has not been studied. The hypothesis that we tested is that ST segment(More)
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