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The Impact of the Gut Microbiota on Human Health: An Integrative View
The human gut harbors diverse microbes that play a fundamental role in the well-being of their host. The constituents of the microbiota--bacteria, viruses, and eukaryotes--have been shown to interactExpand
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Advancing our understanding of the human microbiome using QIIME.
High-throughput DNA sequencing technologies, coupled with advanced bioinformatics tools, have enabled rapid advances in microbial ecology and our understanding of the human microbiome. QIIMEExpand
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Gut Microbiota from Twins Discordant for Obesity Modulate Metabolism in Mice
Introduction Establishing whether specific structural and functional configurations of a human gut microbiota are causally related to a given physiologic or disease phenotype is challenging. TwinsExpand
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Gut Microbiomes of Malawian Twin Pairs Discordant for Kwashiorkor
Not Just Wasting Malnutrition is well known in Malawi, including a severe form—kwashiorkor—in which children do not simply waste away, they also suffer edema, liver damage, skin ulceration, andExpand
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Subsistence strategies in traditional societies distinguish gut microbiomes
Recent studies suggest that gut microbiomes of urban-industrialized societies are different from those of traditional peoples. Here we examine the relationship between lifeways and gut microbiotaExpand
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Subsampled open-reference clustering creates consistent, comprehensive OTU definitions and scales to billions of sequences
We present a performance-optimized algorithm, subsampled open-reference OTU picking, for assigning marker gene (e.g., 16S rRNA) sequences generated on next-generation sequencing platforms toExpand
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Longitudinal analysis of microbial interaction between humans and the indoor environment
Signature microbes follow you from house to house Householders share more than habitation; they also share inhabitants. In a diverse sample of U.S. homes, Lax et al. found that people and animalsExpand
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Defining the human microbiome.
Rapidly developing sequencing methods and analytical techniques are enhancing our ability to understand the human microbiome, and, indeed, how the microbiome and its constituents are defined. ThisExpand
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Genetic control of obesity and gut microbiota composition in response to high-fat, high-sucrose diet in mice.
Obesity is a highly heritable disease driven by complex interactions between genetic and environmental factors. Human genome-wide association studies (GWAS) have identified a number of lociExpand
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The interpersonal and intrapersonal diversity of human-associated microbiota in key body sites.
The human body harbors 10 to 100 trillion microbes, mainly bacteria in our gut, which greatly outnumber our own human cells. This bacterial assemblage, referred to as the human microbiota, plays aExpand
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