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  • Anthony Ryan, Mark Lynch, Sinead M. Smith, Sylvie Amu, Hendrik J. Nel, Claire E. McCoy +14 others
  • 2011
Clostridium difficile is the etiological agent of antibiotic-associated diarrhoea (AAD) and pseudomembranous colitis in humans. The role of the surface layer proteins (SLPs) in this disease has not yet been fully explored. The aim of this study was to investigate a role for SLPs in the recognition of C. difficile and the subsequent activation of the immune(More)
BACKGROUND MicroRNAs (miRNAs) are non-coding RNAs that regulate gene expression by binding to the messenger RNA (mRNA) of protein coding genes. They control gene expression by either inhibiting translation or inducing mRNA degradation. A number of computational techniques have been developed to identify the targets of miRNAs. In this study we used predicted(More)
The past 10 years have seen the description of families of receptors that drive proinflammatory cytokine production in infection and tissue injury. Two major classes have been examined in the context of inflammatory joint disease--the Toll-like receptors (TLRs) and NOD-like receptors (NLRs). TLRs such as TLR2 and TLR4 are being implicated in the pathology(More)
  • Sinéad Nic An Ultaigh, Tajvur P Saber, Jennifer McCormick, Mary Connolly, Jerome Dellacasagrande, Brian Keogh +6 others
  • 2011
INTRODUCTION The aim of this study was to examine the effect of blocking Toll-like receptor 2 (TLR2) in rheumatoid arthritis (RA) synovial cells. METHODS RA synovial tissue biopsies, obtained under direct visualization at arthroscopy, were established as synovial explant cultures ex vivo or snap frozen for immunohistology. Mononuclear cell cultures were(More)
In the 20th century, immunologists focused much of their attention in deciphering the mechanisms of adaptive immunity. As a consequence, tremendous progress was made in the field of adaptive immunity, including tolerance, mechanisms of MHC restriction, the structure and function of MHC receptors, and development and activation of Band T-cells. The reason(More)
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