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The basal ganglia-thalamo-cortical circuits are viewed as segregated parallel feed back loops crucially involved in motor control, cognition, and emotional processing. Their role in planning novel, as compared to overlearned movement patterns is as yet not well defined. We tested for the involvement of the associative striatum (caudate/anterior putamen) in(More)
OBJECTIVE In patients with schizophrenia, impaired hippocampal activation either during encoding or recognition tasks has been observed in a few functional imaging experiments. In this fMRI study, the authors report results of word encoding and recognition in schizophrenia patients and healthy comparison subjects, with a special focus on correcting for(More)
Understanding the relevant meaning of a word with different meanings (homonym) in a given context requires activation of the neural representations of the relevant meaning and inhibition of the irrelevant meaning. The cognitive demand of such disambiguation is highest when the dominant, yet contextually irrelevant meaning of a polar homonym must be(More)
The mesial premotor cortex is crucial for planning sequential procedures and movement initiation. With event-related (ER) functional magnetic resonance imaging (fMRI) it has been possible to separate mesial premotor activation before, during, and after self-initiated movements and, thereby, to distinguish advance planning from execution. The mesial premotor(More)
In this fMRI study, we aimed at identifying the cortical areas engaged in supramodal processing of language comprehension. BOLD changes were recorded in 19 healthy right-handed subjects reading or listening to a story. During the visual control tasks the volunteers attended to a series of continuous letterstrings or a fixation cross, while during the(More)
OBJECTIVE Preterm birth at <32 weeks' gestational age has a specific predilection for periventricular white matter injury. Early prediction of concomitant motor sequelae is a fundamental clinical issue. Recently, functional MRI was introduced as a noninvasive method for investigating the functional integrity of the neonatal brain. We aimed at implementing a(More)
OBJECTIVE To identify biological evidence for Alzheimer disease (AD) in individuals with subjective memory impairment (SMI) and unimpaired cognitive performance and to investigate the longitudinal cognitive course in these subjects. METHOD [¹⁸F]fluoro-2-deoxyglucose PET (FDG-PET) and structural MRI were acquired in 31 subjects with SMI and 56 controls.(More)
Audio-visual integration in the human brain influences perception and precision of motor tasks. We tested audio-visual integration during height estimation when presenting video clips of counter movement jumps (CMJ), using sparse sampling fMRI at 3T. Employing the technique of "sonification", we created artificial auditory-visual motion events by(More)
The medial temporal lobe (MTL) is well known to be crucial for various types of memory; however, controversy remains as to which of its substructures contribute to semantic processing and, if so, to what extent. The current study addresses the issue of MTL contributions to semantic processing during lexico-semantic ambiguity processing by using functional(More)
PURPOSE To determine whether well-described patterns of altered perfusion in schizophrenia can be identified by using continuous arterial spin labeling (CASL) with a whole-brain imaging sequence. MATERIALS AND METHODS This study was approved by the ethics committee of the local institutional review board, and written informed consent was obtained from all(More)