Lukas Lercher

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Maintaining a stable fold for recombinant proteins is challenging, especially when working with highly purified and concentrated samples at temperatures >20 °C. Therefore, it is worthwhile to screen for different buffer components that can stabilize protein samples. Thermal shift assays or ThermoFluor(®) provide a high-throughput screening method to assess(More)
The formation of all-carbon quaternary stereocentres in acyclic systems is one of the most difficult contemporary challenges in modern synthetic organic chemistry. Particularly challenging is the preparation of all-carbon quaternary stereocentres in aldol adducts; this difficulty is problematic because the aldol reaction represents one of the most valuable(More)
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