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PI3K/mTOR Signaling in Mesothelioma Patients Treated with Induction Chemotherapy Followed by Extrapleural Pneumonectomy
Introduction: The prognostic significance of activity biomarkers within the phosphatidylinositol 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) signaling pathway was assessed in two independentExpand
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Colorectal cancer cells display chaperone dependency for the unconventional prefoldin URI1
Chaperone dependency of cancer cells is an emerging trait that relates to the need of transformed cells to cope with the various stresses associated with the malignant state. URI1 (unconventionalExpand
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Importance of excision repair cross-complementation group 1 and ribonucleotide reductase M1 as prognostic biomarkers in malignant pleural mesothelioma treated with platinum-based induction
OBJECTIVES Survival and response to platinum-based induction chemotherapy are heterogeneous among patients with malignant pleural mesothelioma. The aim of the present study was to assess theExpand
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Expression of the Stem Cell Factor Nestin in Malignant Pleural Mesothelioma Is Associated with Poor Prognosis
Background The epithelioid and sarcomatoid histologic variants of malignant pleural mesothelioma (MPM) can be considered as E- and M-parts of the epithelial-mesenchymal transition (EMT) axis; theExpand
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The role of epigenetics and immunological imbalance in the etiopathogenesis of psoriasis and psoriatic arthritis
Psoriasis (Ps) and psoriatic arthritis (PsA) represent a clinical and immunopathogenic continuum, called psoriatic disease, cumulatively affecting approximately 3% of the general population.Expand
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BRAF inhibition sensitizes melanoma cells to α-amanitin via decreased RNA polymerase II assembly
Despite the great success of small molecule inhibitors in the treatment of patients with BRAFV600E mutated melanoma, the response to these drugs remains transient and patients eventually relapseExpand
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Schwere Vitamin-D-Intoxikation: Wie kam es dazu?
Die 58-jährige Patientin ohne internistische oder psychiatrische Vorerkrankungen stellt sich bei seit einer Woche persistierenden Kopfschmerzen, Nausea, Inappetenz und vermehrtem Durstgefühl vor.Expand
Schwere Laktatazidose unter Metformin-Einnahme
Ein 60-jahriger Patient wurde komatos, im Schockzustand, mit akutem Nierenversagen und schwerer Laktatazidose zugewiesen. Er hatte sich kurz zuvor aufgrund von Diarrhoe und Schwache vorgestellt.
Dynamic changes of genomic and transcriptomic tumor diversity during melanoma progression
Metastatic melanoma is an aggressive disease that is notoriously difficult to treat. Here, we used a BRAFV600E-driven mouse model to study melanoma progression and metastasis in the absence ofExpand