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Using Genotype Abundance to Improve Phylogenetic Inference

• William S DeWitt, Luka Mesin, Gabriel D Victora, Vladimir N. Minin, Frederick A. Matsen
• Molecular biology and evolution
• 2018

Modern biological techniques enable very dense genetic sampling of unfolding evolutionary histories, and thus frequently sample some genotypes multiple times. This motivates strategies to incorporate… (More)

One-step generation of monoclonal B cell receptor mice capable of isotype switching and somatic hypermutation.

• Johanne Tracey Jacobsen, Luka Mesin, +5 authors Gabriel D Victora
• The Journal of experimental medicine
• 2018

We developed a method for rapid generation of B cell receptor (BCR) monoclonal mice expressing prerearranged Igh and Igk chains monoallelically from the Igh locus by CRISPR-Cas9 injection into… (More)

Computer Simulation of Multi-Color Brainbow Staining and Clonal Evolution of B Cells in Germinal Centers

• Michael Meyer-Hermann, Sebastian C. Binder, Luka Mesin, Gabriel D Victora
• Front. Immunol.
• 2018

Clonal evolution of B cells in germinal centers (GCs) is central to affinity maturation of antibodies in response to pathogens. Permanent or tamoxifen-induced multi-color recombination of B cells… (More)

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