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Molecular Basis of Tubulin Transport Within the Cilium by IFT74 and IFT81
Cilium Conundrum The cilium has emerged as the antenna of eukaryotic cells, having numerous functions in sensory reception and developmental signaling. Several disorders, such as polycystic kidneyExpand
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Cep164 triggers ciliogenesis by recruiting Tau tubulin kinase 2 to the mother centriole
Significance The primary cilium is an organelle typically found on postmitotic vertebrate cells. Cilia serve as antennae to receive signals from extracellular space and thus play important roles inExpand
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Wnt5a cooperates with canonical Wnts to generate midbrain dopaminergic neurons in vivo and in stem cells
Wnts are a family of secreted proteins that regulate multiple steps of neural development and stem cell differentiation. Two of them, Wnt1 and Wnt5a, activate distinct branches of Wnt signaling andExpand
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The E3 ubiquitin ligase Mib1 regulates Plk4 and centriole biogenesis
Centrioles function as core components of centrosomes and as basal bodies for the formation of cilia and flagella. Thus, effective control of centriole numbers is essential for embryogenesis, tissueExpand
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The centrosome duplication cycle in health and disease
Centrioles function in the assembly of centrosomes and cilia. Structural and numerical centrosome aberrations have long been implicated in cancer, and more recent genetic evidence directly linksExpand
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Differentiation of neural rosettes from human pluripotent stem cells in vitro is sequentially regulated on a molecular level and accomplished by the mechanism reminiscent of secondary neurulation.
Development of neural tube has been extensively modeled in vitro using human pluripotent stem cells (hPSCs) that are able to form radially organized cellular structures called neural rosettes. WhileExpand
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An Efficient Method for Generation of Knockout Human Embryonic Stem Cells Using CRISPR/Cas9 System.
Human embryonic stem cells (hESCs) represent a promising tool to study functions of genes during development, to model diseases, and to even develop therapies when combined with gene editingExpand
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Inactivation of PLK4-STIL Module Prevents Self-Renewal and Triggers p53-Dependent Differentiation in Human Pluripotent Stem Cells
Summary Centrioles account for centrosomes and cilia formation. Recently, a link between centrosomal components and human developmental disorders has been established. However, the exact mechanismsExpand
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KIF14 controls ciliogenesis via regulation of Aurora A and is important for Hedgehog signaling
Pejskova et al. find that KIF14 is required for cilia formation and KIF14 loss leads to Hedgehog signaling defects. The study pinpoints deregulated Aurora A activity as a downstream mediator of KIF14Expand
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Phosphorylation of multiple proteins involved in ciliogenesis by Tau Tubulin kinase 2
Primary cilia are organelles necessary for proper implementation of developmental and homeostasis processes. To initiate their assembly, coordinated actions of multiple proteins are needed. TauExpand
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