Luiza Helena Gremski

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Venomous animals use their venoms as tools for defense or predation. These venoms are complex mixtures, mainly enriched of proteic toxins or peptides with several, and different, biological activities. In general, spider venom is rich in biologically active molecules that are useful in experimental protocols for pharmacology, biochemistry, cell biology and(More)
Loxoscelism is the designation given to clinical symptoms evoked by Loxosceles spider's bites. Clinical manifestations include skin necrosis with gravitational spreading and systemic disturbs. The venom contains several enzymatic toxins. Herein, we describe the cloning, expression, refolding and biological evaluation of a novel brown spider protein(More)
Background Hepatic steatosis refers to the accumulation of triglycer-ides in hepatocytes, and it can be attributed to excessive ethanol consumption. The liver is the main organ of etha-nol biotransformation and therefore, it can suffer with oxi-dative stress generated by ethanol. Since the FXR agonist 6ECDCA regulates adipose cell function, the aim of this(More)
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