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INTRODUCTION Human migration and the presence of natural vectors (mollusks) of Schistosoma mansoni are the primary causes of the expansion of mansoni schistosomiasis into southern areas of South America. Water conditions are favorable for the expansion of this disease because of the extensive hydrographic network, which includes the basins of the Paraná and(More)
The analysis of the genetic variability related to susceptibility to Schistosoma mansoni infection in the vector of the genus Biomphalaria is important in terms of a better understanding of the epidemiology of schistosomiasis itself, the possible pathological implications of this interaction in vertebrate hosts, and the formulation of new strategies and(More)
Schistosoma mansoni is the most widespread of the human-infecting schistosomes, present in 54 countries, predominantly in Africa, but also in Madagascar, the Arabian Peninsula, and the Neotropics. Adult-stage parasites that infect humans are also occasionally recovered from baboons, rodents, and other mammals. Larval stages of the parasite are dependent(More)
Hypoxanthine-guanine phosphoribosyltransferase (HGPRTase) is an essential gene of the parasite Schistosoma mansoni and it is well conserved in its hosts (mouse and human) at the protein but not at the RNA level. This feature prompted us to assess RNA interference (RNAi) to combat schistosomiasis. Small interfering RNAs (siRNAs) were produced against(More)
The historical phylogeography of the two most important intermediate host species of the human blood fluke Schistosoma mansoni, B. glabrata in the New World, and B. pfeifferi in the Old World, was investigated using partial 16S and ND1 sequences from the mitochondrial genome. Nuclear sequences of an actin intron and internal transcribed spacer (ITS)-1 were(More)
OBJECTIVE The infection ability of miracidia of BH and SJ strains of S. mansoni, obtained from mice infected with cercariae taken from Biomphalaria glabrata and Biomphalaria tenagophila, genetically selected for susceptibility is compared with the infection ability of miracidia obtained from mice infected with larvae from non-selected mollusks. MATERIAL(More)
The present paper reports the comparison between a newly isolated strain of S. mansoni in the city of Campinas (SP, Brazil) named SR, with the strains BH (Belo Horizonte, MG, Brazil) and SJ (São José dos Campos, SP, Brazil). The study was done using mice experimentally infected with 70 cercariae from sympatric snails: B. glabrata for the BH strain and B.(More)
The influence of the susceptibility of the vector snails of S. mansoni on the development of the pathogenicity of the worm to the host was studied. Off-spring of snails Biomphalaria glabrata and Biomphalaria tenagophila were used, selected with regard to the susceptibility to S. mansoni of the strains BH and SJ trait, respectively. Parenteral, F1, F2, F3(More)
The relationship between the development of hepatomegaly, splenomegaly, body weight and mortality rate and the degree of susceptibility of Biomphalaria glabrata and B. tenagophila at which infective cercariae developed was studied. The study utilized Swiss mice, SPF, as definitive hosts and populations of snails genetically selected for character(More)