Luiz A. V. C. Meyer

Learn More
BACKGROUND Defects in BRCA1, BRCA2, and other members of the homologous recombination pathway have potential therapeutic relevance when used to support agents that introduce or exploit double-stranded DNA breaks. This study examines the association between homologous recombination defects and genomic patterns of loss of heterozygosity (LOH). METHODS(More)
Increases in corneal endothelial cell polymegathism and pleomorphism are characteristic of diabetic human and dog corneas. This study investigated the rat as a model for age- and diabetes-related changes in endothelial cell morphology. As in most mammals, aging of the normal rat results in a progressive decrease in cell density as well as reduced numbers of(More)
In many scientific workflows, particularly those that operate on spatially oriented data, jobs that process adjacent regions of space often reference large numbers of files in common. Such workflows, when processed using workflow planning algorithms that are unaware of the application's file reference pattern, result in a huge number of redundant file(More)
The execution of scientific workflows in Grid environments imposes many challenges due to the dynamic nature of such environments and the characteristics of scientific applications. This work presents an algorithm that dynamically schedules tasks of workflows to Grid sites based on the performance of these sites when running previous jobs from the same(More)
Corneal inflammation is frequently associated with the development of corneal edema. It has been suggested the development of corneal edema might in some way be related to the presence of polymorphonuclear leukocytes (PMNLs) within inflamed corneas. In the present studies, it was found that corneal thickness markedly increased after experimental infection(More)
After transcorneal freezing, physiologic function (pump and barrier) of the regenerating rabbit corneal endothelium was evaluated and compared with the morphologic differentiation that occurs during wound healing. Endothelial pump function was investigated utilizing the specific binding of tritiated ouabain to endothelial Na+/K+ ATPase (pump sites); the(More)