Luise M C Wheat

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AbstractNew therapies are required for chronic lymphocytic leukemia (CLL), an incurable disease characterized by failure of mature lymphocytes to undergo apoptosis. Activation of cell surface death receptors, such as via TRAIL receptor ligation, may provide a novel therapeutic target for various malignancies. However, CLL and other lymphoid malignancies are(More)
Integrative genomic and gene-expression analyses have identified amplified oncogenes in B-cell non-Hodgkin lymphoma (B-NHL), but the capability of such technologies to localize tumor suppressor genes within homozygous deletions remains unexplored. Array-based comparative genomic hybridization (CGH) and gene-expression microarray analysis of 48 cell lines(More)
Epidemiological studies indicate the involvement of environmental factors in the etiology of breast cancer, but have not provided clear indications of the nature of the agents responsible. Several environmental carcinogens are known to induce mammary tumors in rodents, and the abundance of adipose tissue in the human breast suggests that the epithelial(More)
allografted (n1⁄4 7), NPMm/non-allografted (n1⁄4 27), NPMwt/ allografted (n1⁄4 25) and NPMwt/non-allografted (n1⁄4 16) patients. NPM status had a prognostic effect only in nonallografted patients (median not reached for NPMm, 24.4 months for NPMwt; P1⁄4 0.04). Indeed, the NPMwt/non-allografted patients had a very poor 3 years OS compared to the other(More)
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