Luisa Bracci Laudiero

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We describe the measurement of beta-nerve growth factor (NGF) content in cerebrospinal fluid (CSF) from multiple sclerosis (MS) patients compared with CSF from age-matched normal subjects using a specific sandwich immunoassay (ELISA). During acute attacks patients exhibit a significant increase of NGF content compared to controls. In contrast during(More)
Megalencephalic leukoencephalopathy with subcortical cysts (MLC) is a rare leukodystrophy caused by mutations in the gene encoding MLC1, a membrane protein mainly expressed in astrocytes in the central nervous system. Although MLC1 function is unknown, evidence is emerging that it may regulate ion fluxes. Using biochemical and proteomic approaches to(More)
NGF exerts a broader biological action than previously believed. The growing-evidence of NGF's effect on lymphocytes and the presence of high levels of mRNA for NGF receptors in the embryonic bursa of Fabricius led us to study the action of NGF on bursal cells during chick embryo development. Our in vivo experiments indicate that NGF administration in ovo(More)
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